There have been several recent papers about how statins prevented mental decline, however none of those I saw stratified patients by ApoE status. I just found one from June 2020 that did that: Telmisartan and Rosuvastatin Synergistically Ameliorate Dementia and Cognitive Impairment in Older Hypertensive Patients With Apolipoprotein E Genotype. It was a placebo-controlled trial where participants (hypertensive people over 60 with no cognitive impairment) were randomized to receive either, both, or neither of the anti-hypertension drug telmisartan (dosage 40 mg/day, increased to 80 mg/day if needed) or the hydrophilic statin drug rosuvastatin (10 md/day) and followed up for 7 years. The participants were also genotyped for their ApoE status.
While all participant populations declined mentally *on average* over the course of the follow-up, receiving either drug reduced the rate of decline, and receiving both together reduced it even more. And this was true also for participants who were ApoE4 positive!
statin and sartan drugs in ApoE4+ patients
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