Hormone Replacement Therapy E4 Women

[slacker]

New study by Roberta Diaz Brinton's group.

Thanks for sharing!

[circular]

New study by Roberta Diaz Brinton's group...

Thank you for posting that! n = 379,352 women!

[SusanJ]

From Weill Cornell Medicine researchers, in collaboration with the University of Arizona:

All menopausal groups exhibited lower GMV in AD-vulnerable regions as compared to men, with peri-menopausal and post-menopausal groups also exhibiting lower GMV in temporal cortex as compared to the pre-menopausal group. Reproductive span, number of children and pregnancies, use of HT and HC were positively associated with GMV, chiefly in temporal cortex, frontal cortex, and precuneus, independent of age, APOE-4 status, and midlife health indicators. Although reproductive history indicators were not directly associated with cognitive measures, GMV in temporal regions was positively associated with memory and global cognition scores.

https://n.neurology.org/content/early/2 ... 0000012941

GMV is gray matter volume. HT is hormonal therapy and HC is hormonal contraceptives.

Article behind a paywall.

Here's a summary of the research if you don't want to search for the paper.

[circular]

From Weill Cornell Medicine researchers, in collaboration with the University of Arizona:

All menopausal groups exhibited lower GMV in AD-vulnerable regions as compared to men, with peri-menopausal and post-menopausal groups also exhibiting lower GMV in temporal cortex as compared to the pre-menopausal group. Reproductive span, number of children and pregnancies, use of HT and HC were positively associated with GMV, chiefly in temporal cortex, frontal cortex, and precuneus, independent of age, APOE-4 status, and midlife health indicators. Although reproductive history indicators were not directly associated with cognitive measures, GMV in temporal regions was positively associated with memory and global cognition scores.

https://n.neurology.org/content/early/2 ... 0000012941

GMV is gray matter volume. HT is hormonal therapy and HC is hormonal contraceptives.

Article behind a paywall.

Here's a summary of the research if you don't want to search for the paper.

Thanks. That's quite an interesting. I wonder if # of children and other exposures to estrogen could cancel each other out to any degree. In other words, for women who don't have children, by choice or circumstance, can HC + HT sufficiently offset the benefit that pregnancies and having children can provide? I hate to think that women should feel pressure to have a family that includes their own children in order to decrease their chances of later cognitive decline. The second link to the summary provides some hope that subsequent research will delve into that more:

"We're hoping now to get further into the details of these links between estrogen and GMV, for example by comparing the effects of surgical menopause and spontaneous menopause, and by focusing specifically on certain types of estrogen exposure, such as menopause hormone therapy," said study first author Eva Schelbaum, research assistant in Dr. Mosconi's laboratory. [Emphasis added]

[NS99]

Hi all, new to this site and just wondered if anyone can recommend any Drs in the UK who understand hormones and the link to dementia (and prescribe HRT). I've been desperately trying to find someone who understands early perimenopause (itself a risk factor for dementia), only to discover I also have a copy of APOE 4...

I've checked in the recommended practitioners list but there is nothing relevant.

Thanks in advance!

[SBee]

Hi all, new to this site and just wondered if anyone can recommend any Drs in the UK who understand hormones and the link to dementia (and prescribe HRT). I've been desperately trying to find someone who understands early perimenopause (itself a risk factor for dementia), only to discover I also have a copy of APOE 4...

I've checked in the recommended practitioners list but there is nothing relevant.

Thanks in advance!

Hello NS99 and a warm welcome to you!
Thank you so much for posting your question about physicians who are versed in potential links between dementia and early perimenopause/HRT. I'm sorry you were unable to find someone via the recommended practitioners list. One of our senior contributors suggested that Lisa Moscone’s book, The XX Brain could be a helpful resource for you and your Ob/Gyn. Other members might be able to assist you with some additional suggestions!

As you continue to explore the site, may I offer these tools/resources to support you:

The Primer is a detailed and informative resource written by a practicing M.D. with ApoE4/4. It includes information about the biochemistry of the ApoE4 gene and offers a variety of research-based prevention strategies.

The How-To Guide offers tips on how to navigate forums and respond to posts including how to quote members (use the quotation icon in the upper right of any post) so they get an email notification of your post. It also demonstrates how to use the Search function for topics, and how to subscribe to topics of interest in the forums.

Finally, Our Stories includes stories of other community members. You may wish to share your own story in this section if you feel comfortable doing so.

I hope you find these tools useful as you continue to navigate the site. Please feel free to reach out if you have any additional questions!

Warmly,
Sue

[NS99]

Thanks so much Sue - and apologies for my slow reply, I hadn't realised you had responded!

[floramaria]

Thanks so much Sue - and apologies for my slow reply, I hadn't realised you had responded!

Hi NS99, this is from our Wiki on ApoE4 aware health providers:
Functional Medicine Associates; London, U.K.[edit]
Functional Medicine Associates are a group of experienced IFM certified practitioners with additional Bredesen and Kharrazian Institute training in dementia and Nero-cognitive issues. We use a systems biology approach, explore root causes and provide a positive pathway for people with manifestations of cognitive decline and in particular ApoE4 patients.

Website: https://www.functional-medicine.associates
Phone: +44 7388 812179
Email: info@fm.associates
Address: 51 New Cavendish St, London W1G 9TG

You could also use the Search function to see if there are other posts about providers in the UK. You access that just under your user name. I'd suggest entering various searches to turn up all relevant results. Good luck!

[NS99]

Great, thank you Floramaria!