ApoE peptides important regardless of individual variant

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
Post Reply
User avatar
SusanJ
Senior Contributor
Senior Contributor
Posts: 3058
Joined: Wed Oct 30, 2013 7:33 am
Location: Western Colorado

ApoE peptides important regardless of individual variant

Post by SusanJ »

Just another reminder that everyone needs to take care of their brains, regardless of ApoE variant.
The data also revealed a close correlation between dementia diagnosis and the detection of ApoE peptides in the brain. The correlation with dementia for ApoE was even stronger than that seen for Tau, Aβ, or α-Synuclein. Moreover, the ApoE peptides were significantly enriched even in dementia patients who lack the APOE ε4 allele. The results emphasize the relevance of the ApoE protein as an aberrantly aggregated protein in its own right, rather than just an "upstream" genetic risk factor.

"Our study adds to an evolving appreciation of multiple misfolded proteins in the human brain and moves the field forward by emphasizing that ApoE may be a stong contributor to the dementia prototype, even in individuals who do not have the disease-driving version of the APOE gene," said Dr. Nelson. "Even in persons lacking the APOE ε4 allele, ApoE may indeed be among the most impactful 'gloppy proteins' in aging brains."
Here are the overview and the full paper.
Post Reply