In People Who Defy ApoE, New Alzheimer’s Risk Genes Found

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mike
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In People Who Defy ApoE, New Alzheimer’s Risk Genes Found

Post by mike »

It is not just ApoE - more Big Data insights.
ApoE2 lowers Alzheimer’s risk; ApoE4 raises it. But what explains the people who buck this trend—i.e., the ApoE2 carriers who get AD, and ApoE4 carriers who stay free of it into old age? In the December 7 Alzheimer’s and Dementia, researchers led by Olivier Lichtarge at Baylor College of Medicine in Houston used evolutionary genetics to investigate this question. The researchers hunted for genetic variants associated with these so-called paradoxical phenotypes. They identified more than 200 genes that may either shield ApoE4 carriers from AD, or render ApoE2 carriers vulnerable to it.
https://www.alzforum.org/news/research- ... enes-found
Sonoma Mike
4/4
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