Gail wrote: ↑Thu Aug 18, 2022 8:37 am
I am hedging my bets and taking 1 ml liter of of the Prodrome Nuero (but not 3 ml). I'm also taking lots of phosphatidylcholine as you pointed out I have the PEMT mutation and need supplementation. I'm hoping this will do it.
Sorry it has taken me so long to get back to this thread, Gail.
I've been reading about TMAO and running my own (smelly) experiment with garlic.
Today I read an article comparing allicin levels of fresh raw garlic with dried garlic capsules, tablets, and tablets with enteric coating. I was driven to read this after my husband complained that the smell of the raw garlic I've been eating when I eat choline rich foods was seeping from my skin.
Today I ordered some tablets.
Allicin Bioavailability and Bioequivalencd from Garlic Supplements https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073756/
The information I got earlier suggesting I avoid choline came from Gut Intelligence test from Viome.
Almost every food containing choline was in the list of foods I should completely avoid! The reason they gave was : "-(Name of food) contains choline that can be used by your microbes to produce TMA, a precursor to TMAO. TMAO is associated with unwanted metabolic and cardiovascular effects.
TMA is created in the gut by microbes when certain compounds, such as choline and carnitine, are present. TMA can then be converted into TMAO in the liver and enter the bloodstream. High levels of TMAO are associated with unfavorable metabolic and cardiovascular effects. …If your score is Not Optimal, limiting or avoiding foods and supplements high in choline and carnitine may be helpful.
Since I want to supply myself with high levels of choline, I'm trying to work around the TMA production in my microbiome.
I remembered in another thread, there was an article about some foods inhibiting TMA production .
This is the post From this thread:
“Animal products contain L-carnitine, choline and choline-contributing compounds. These molecules are metabolized by gut bacteria into trimethylamine (TMA), which is converted in the liver to trimethylamine-N-oxide(TMAO), a compound linked to coronary events. Garlic, extra-virgin olive oil and red wine, staple ingredients of the Mediterranean diet, reduce the production of TMAO through allicin and 3,3-dimethylbutan-1-ol (DMB), compounds that block TMA production by gut bacteria.“
Tincup's post above has a link to a video great information about taking garlic to reduce TMAO damage.
There are also a lot of studies suggesting that resveratrol is useful in protecting against damage from TMAO. This is one of the best:
The title of the article is “Resveratrol Attenuates Trimethylamine-N- Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota”. Here is a link.
I'd be happy to compare our ProdromeScan experiences via phone or videoconference if you are still interested in doing that.