rs2075650

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
Jgreg80
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Re: rs2075650

Post by Jgreg80 »

The meta-analysis shows a 38% risk reduction, but again I’m not sure if it’s AA vs GG or AA+AG vs GG. Either way, that’s quite a lot for a single SNP. rs157580 is in weak linkage disequilibrium with APOE e4. I inherited APOE e4 from my mother, but not her G allele.
Max100
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Re: rs2075650

Post by Max100 »

Jgreg80 wrote: Mon Sep 26, 2022 1:07 pm The meta-analysis shows a 38% risk reduction, but again I’m not sure if it’s AA vs GG or AA+AG vs GG. Either way, that’s quite a lot for a single SNP. rs157580 is in weak linkage disequilibrium with APOE e4. I inherited APOE e4 from my mother, but not her G allele.
I’m a 3/4 with an A/G but the meta analysis seems to refer to this SNP as “protective” so not sure where this falls for me on risk.

“Two SNPs (rs3764650 and rs2075650) were found to be significantly associated with increased risk of AD, whereas the other 2 SNPs (rs3865444 and rs157580) were significantly associated with a decreased risk of AD. “

157580 is repeatedly referred to as a decreased risk or “protective.” That’s where I’m getting the implication that there’s not necessarily a punitive effect from baseline with any G allele. Just trying to wrap my head around the implications of this SNP.
Jgreg80
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Re: rs2075650

Post by Jgreg80 »

If they used A as the reference allele, then G would be considered higher risk. The math is the same, just reversed.

And btw, AG is very common.
Max100
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Re: rs2075650

Post by Max100 »

Jgreg80 wrote: Mon Sep 26, 2022 1:47 pm If they used A as the reference allele, then G would be considered higher risk. The math is the same, just reversed.

And btw, AG is very common.
Thanks for the back and forth. It’s time for me to put this SNP to bed and find another to stress about 🙁
TLS
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Re: rs2075650

Post by TLS »

Promethease has this to say about the gene.

"Recent work suggests, however, that the linkage disequilibrium between rs2075650 and the ApoE ε4 defining SNP rs429358 means that there may be little, if any, independent effect of rs2075650 on Alzheimer's risk.

Located close to ApoE4, yet may independently (also) influence risk of Alzheimer's disease. A case-control study of 381 patients found a 2x higher risk for Alzheimer's disease associated with the rarer rs2075650(G) allele. This allele is associated with earlier onset of Alzheimer's disease, by ~7 years. ( news) The data from this study are available online at http://users.loni.usc.edu/~thompson/L/1 ... AD2011.pdf. The association of this SNP with late-onset Alzheimer's disease was confirmed by a study reported in PLoS Genetics. The A allele of this SNP is one of 150 identified as relevant to exceptional longevity in Recent work suggests, however, that the linkage disequilibrium between rs2075650 and the ApoEε4 defining SNP rs429358 means that there may be little, if any, independent effect of rs2075650 on Alzheimer's risk."
apoe 3/4
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