AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

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J11
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Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Post by J11 »

Julie G, Chicagogirl has given me an eviction notice so I will not take over the thread with my comments.

Nevertheless, the Lecanemab safety issue is still worth a brief rebuttal here and more on the Aducan thread. From what I now understand the recently reported fatality was in the long term extension and not the phase 3. This seems likely as the side effects with most mabs appear to happen typically early on in treatment. 5 months ago all of the on treatment phase 3 patients would have been treated for 15 months. I found this of interest because I wonder to what extent the per protocol phase 3 patients might have been different from the per protocol long term extension patients. Perhaps the exclusions were stricter during the phase 3.
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Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Post by Chicagogirl »

J11 wrote: Tue Nov 01, 2022 5:54 pm Julie G, Chicagogirl has given me an eviction notice so I will not take over the thread with my comments.
I had suggested that maybe there could be two threads. One for the mechanics on what happens when joining the trial and another for all the scientific and medical detail under a lecanemab thread, not the adum thread. I absolutely respect the information that you provided and the detail that you delve into. I think the knowledge that you have and the way you present it is phenomenal.

It can all be presented in one thread on this forum. Sorry, I did not intend for it to be viewed as an eviction notice.

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Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Post by J11 »

Chicagogirl, thank you for your reply.

I appreciate your clarification as online it is even more difficult for me to understand theory of mind issues than in day to day life.

This is such a monumental moment for the global AD community; the Lecanemab presentation at CTAD will happen this month! I am so grateful for the efforts that the pharmaceutical companies have made over many decades to move us to where we are now. The products that are in development will offer me a safe and effective means of countering AD pathology when needed at the earliest stages.

It means so much to me knowing that I will not descend into the dementing illness that all previous generations of my family experienced. When I started the Aducan thread I could feel the clock ticking down ... they wanted another 5 year confirmatory trial and then something might not be quite right ... at some point you just run out of road and your cognition declines and there is nothing that can help and it keeps declining. The Clarity results for Lecanemab were not exactly a surprise to me (especially after spending years on the Aducan thread trying to understand how amyloid removal relates to cognition in early AD and then the Clarity trial landed exactly on the regression line), though it is still surprising to arrive in the future and find that it all worked to plan and we got to the ... and everyone lived happily ever after part.

From where we stand now, I am fairly confident that I will not even reach the MCI stage. I might have years to prepare for preventative AD treatment. There is already a tidal wave of dementia drugs approaching and even more are entering clinical trials.
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Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Post by Julie G »

I had suggested that maybe there could be two threads. One for the mechanics on what happens when joining the trial and another for all the scientific and medical detail under a lecanemab thread, not the adum thread.
This is great idea, Chicagogirl. I'll start a new thread about lecanamab benefits/side effects.
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Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Post by Chicagogirl »

.
My journey for those who are considering this study:

I haven't posted since October 14th when I completed the 1B visit. It seemed to take longer than I expected for the results to be reviewed and approved. (It has only been 1 month, but it seems like a long time to me). I passed the cognitive and medical tests. I am now eligible for Visit 2 which is the Amyloid PET Scan. Unfortunately, this will not occur until January since their PET Scanner is being removed and replaced. It will then need to go through the normal certification before it can be used.

If you have questions about the process or just want to talk about your experience, you can always PM me. Or you can post here so those in the study will feel some comfort knowing there are others in this trial. If you post here, you might get answers from others in the trial also.

OTHER INFORMATION: There is CTAD (Clinical Trials on Alzheimers Disease) Conference on November 29th. They will be reporting on the Phase 3 Lecanemab trial CLARITY. This is a trial for those with MCI or mild Alzheimers.

There will be a number of individuals analyzing this information. Look for it in the following thread set up by Julie G to handle the scientific and medical discussion of LECANAMAB (there are already some posts there):

LECANAMAB: EFFICACY, SIDE EFFECTS, AND MORE

Happy Thanksgiving to everyone!
;) 4/4 “Choose to be optimistic. It feels better.” Dalai Lama
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Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Post by Julie G »

I haven't posted since October 14th when I completed the 1B visit. It seemed to take longer than I expected for the results to be reviewed and approved. (It has only been 1 month, but it seems like a long time to me). I passed the cognitive and medical tests. I am now eligible for Visit 2 which is the Amyloid PET Scan. Unfortunately, this will not occur until January since their PET Scanner is being removed and replaced. It will then need to go through the normal certification before it can be used.

If you have questions about the process or just want to talk about your experience, you can always PM me. Or you can post here so those in the study will feel some comfort knowing there are others in this trial. If you post here, you might get answers from others in the trial also.
I'm sure it's very frustrating to have to wait for the next step — so sorry. Nonetheless, huge thanks for continuing to share your experience; you are truly a pioneer. Like many, I'll be looking forward to more info on phase 3.
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Re: AHEAD 3-45 STUDY CLINICAL TRIAL (LECANEMAB - BAN 2401)

Post by Chicagogirl »

To follow information on the CTAD Conference next week, check out another thread in the APOE 4 site. There is already information on Lecanemab in the Clarity trial posted there and I am sure next week there will be a lot more.

viewtopic.php?t=8179

"CTAD 2022 -- Endgame for AD"

AND

LECANAMAB: EFFICACY, SIDE EFFECTS, AND MORE. viewtopic.php?t=8303
;) 4/4 “Choose to be optimistic. It feels better.” Dalai Lama
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