Gene Therapy Trial for ApoE4 Homozygotes

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TheresaB
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Re: Gene Therapy Trial for ApoE4 Homozygotes

Post by TheresaB »

The initial data from Lexeo Therapeutics on their APOE4 homozygous Alzheimer’s disease clinical trial has been released. Of note, they are still enrolling patients and adding 2 more US sites for the trial. To learn more, click this link:

LEXEO THERAPEUTICS ANNOUNCES POSITIVE INITIAL DATA FROM ONGOING PHASE 1/2 CLINICAL TRIAL OF AAV-BASED GENE THERAPY CANDIDATE LX1001 IN PATIENTS WITH ALZHEIMER’S DISEASE
-Theresa
ApoE 4/4
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Brian4
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Re: Gene Therapy Trial for ApoE4 Homozygotes

Post by Brian4 »

Here's a bit more up-to-date info (more patients) from CTAD:

https://www.nytimes.com/2022/12/02/heal ... erapy.html

Brian
Karina52
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Re: Gene Therapy Trial for ApoE4 Homozygotes

Post by Karina52 »

Read a New York Times article yesterday about APOE2 gene therapy for 4/4 homozygotes. Since I am one of the admins of the APOE4/4 group on Facebook, I emailed one of the doctors (Dr. Samuel Gandy) last night and he responded this morning, introducing me to the research team at Weill Cornell. Dr. Michael Kaplitt then emailed me with the following:
"We certainly would love to interact with your members since this is the group that we are trying to help at present. The major criteria for the study is that patients have to be 50 years or older and be positive for both copies of ApoE4 and have mild to moderate dementia. There are a variety of other technical criteria that we evaluate in our workup if they have not already been done (they have to have a PET scan that is positive for amyloid and they have to have certain spinal fluid markers of Alzheimer’s disease) but if someone is an ApoE4/E4 with some cognitive impairment that is not too severe and they are old enough, then we would love to talk with them if they are interested and we can figure out the additional testing if appropriate.
We are still recruiting for this study so I have also copied our study coordinator Haley Bowe who helps with recruitment and initial screening and with logistics. She can provide contact information if you would like to include that in your Facebook posting.
If you would like any additional information, please feel free to reach out to me any time.
Thank you for your interest and we look forward to working with your group."
Her contact info is hab4007@med.cornell.edu for anyone interested!
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