Mitochondria

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
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TLS
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Mitochondria

Post by TLS »

I listened to 2 excellent discussions on the possibility that mitochondria could be at the root of Alzheimer's disease.

Bioenergetics: How Mitochondria Affects Alzheimer’s Disease and Aging
Interview of Russell Swerdlow, MD, director, Kansas Alzheimer’s Disease Research Center, director, Heartland Center for Mitochondrial Medicine, professor of neurology, University of Kansas. He is a clinician who takes care of patients and a researcher.

Highlights:
Yeah, there's really no doubt that mitochondria are altered in Alzheimer's disease. We've known that for decades. Even back in the 1970s people doing work with electron microscopy noted that mitochondria just looked different in the brains of Alzheimer's patients.

Eventually, we reach a point where our mitochondria change enough that they trigger the proteostasis changes that we appreciate in Alzheimer's disease, the plaques and the tangles, and also a number of systems changes, like inflammation and insulin resistance changes in lipid biology, that we see in Alzheimer's patients. Those systems changes and proteostasis changes may then feed forward and further impact the mitochondria, or not, but as an individual continues to age and their mitochondria continue to decline the thought is that we reach a point that we can no longer compensate and we depart from a state of compensated aging to a state of decompensated aging and experience the cognitive decline in dementia and the degeneration of Alzheimer's disease.

Exercise and a ketogenic diet are good for mitochondria.

Show Transcript is included for those who prefer to read instead of listen to a podcast:
https://www.adrc.wisc.edu/dementia-matt ... -and-aging

Huberman Lab interview with Chris Palmer, M.D., a board-certified psychiatrist and assistant professor of psychiatry at Harvard Medical School.

Fascinating interview, that is long and discusses the brain, how low carb/ketosis can help with psychiatric disorders and also Alzheimers. I plan to listen to it again as there was so much information in the session. The link below is to the show notes and they are broken out by subject if you want to skip, but I really recommend listening to the whole interview because it provides a ton of background information that I found to be helpful in understanding the brain.

Topics of interest include diet, alcohol, ketone salts, studies, and fasting to name a few!

https://hubermanlab.com/dr-chris-palmer ... al-health/

I plan to re-read this site's wiki https://wiki.apoe4.info/wiki/Mitochondria too!
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Bettylacy
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Re: Mitochondria

Post by Bettylacy »

Hi TLS-
I have recently finished reading Brain Energy by Christopher Palmer and listening to his interview on the Tim Ferris show-https://tim.blog/2022/11/12/chris-palmer-transcript. I am impressed with Dr Palmer's view linking mental illness/brain disorders to mitochondria and improvement to the ketogenic diet. On his website, you can see interviews with clients who have had improvement with symptoms. Very fascinating. I enjoyed looking at transcripts of the interview with Dr Swerdlow. So many interesting connections with mitochondria and neurodegenerative disease. And of course, recognizing these changes in the mitochondria are not just in the brain but in all other tissues. I plan to keep reading on this topic and listen to the hubermanlab interview. Thanks for sharing.
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