Choline for Apoe4

[Amykwill]

Has anyone heard about this? Wondering if there is any downside to adding extra Choline to my already long list of supplements
https://news.mit.edu/2021/study-offers- ... imers-risk

[circular]

Has anyone heard about this? Wondering if there is any downside to adding extra Choline to my already long list of supplements
https://news.mit.edu/2021/study-offers- ... imers-risk

Thank you for linking to that explanation about why choline appears to be especially important for people with ApoE4. I had never heard it explained quite like that. It made me feel a bit better about eating more animal protein than some others here. I prefer to get as much of my nutrition as possible through food. Despite eating plenty of animal protein (typical daily intake: 2 eggs, 1 serving of fish or seafood, 1 serving of poultry that I occasionally substitute with red meat), it can still be hard to get enough choline through diet. When I supplemented with choline my TMAO was high. When I stopped it went down, despite that my diet was high in choline. Some believe TMAO raises risk for cardiovascular disease, while others are not convinced of that. I haven't been supplementing, but I might consider a low dose to be sure I'm meating ( ) my daily requirement.

[floramaria]

Has anyone heard about this? Wondering if there is any downside to adding extra Choline to my already long list of supplements
https://news.mit.edu/2021/study-offers- ... imers-risk

I don't know of a downside. Choline deficiency is widespread. I take citicoline . From a Google search:
Citicoline is considered a dietetic source of choline and cytidine. ... It is hypothesized that, compared to choline moiety in other dietary sources such as phosphatidylcholine, choline in citicoline is less prone to conversion to trimethylamine (TMA) and its putative atherogenic N-oxide (TMAO).

[circular]

From a Google search:
Citicoline is considered a dietetic source of choline and cytidine. ... It is hypothesized that, compared to choline moiety in other dietary sources such as phosphatidylcholine, choline in citicoline is less prone to conversion to trimethylamine (TMA) and its putative atherogenic N-oxide (TMAO).

Thanks for that floramaria! I had never heard it. Here's a link to the 2019 paper if anyone wants to see it:

Citicoline: A Superior Form of Choline?

I know I was supplementing with phosphatidylcholine when my TMAO was high. I think I will see if this paper's conclusion is seen in my own physiology by taking citicholine and retesting TMAO.

[Bharati]

We have organic sunflower lecithin powder everyday on our small bowl of berries. I have managed to reduce my homocysteine level from 9.3 µmol/L to 7.1 µmol/L since doing this for most of this year. We also have eggs virtually every day!

[NewRon]

I'm not sure how many participating in this discussion have prostates glands...but my PSA has gone from about 1.5 to 2.3 in the last year, having started eating a few more eggs and commencing Jarrow CDP Citcholine 250mg/day.....

[Tincup]

I'm not sure how many participating in this discussion have prostate glands...but my PSA has gone from about 1.5 to 2.3 in the last year, having started eating a few more eggs and commencing Jarrow CDP Citcholine 250mg/day.....

I stopped eating eggs in January 2021 as one our Gundry tests showed me spiking for autoimmune reasons on both whites and yolks. However, prior to that I commonly ate at least 6 eggs/day along with shellfish and my Nov 2020 test (prior to stopping eggs) was 0.4.ng/mL. It has ranged 0.3-0.4 for years, so at least for me, no correlation. I do consume a 1.5 tablespoons of powdered sunflower lecithin/day now, but haven't rerun the PSA.

[sarahb12]

I remember when I was pregnant, I read studies about choline helping memory and that it was implicated (maybe wi rodent studies) that choline during pregnancy and breastfeeding protected against AD later in life. I've taken choline or eaten eggs frequently since then.

[VLB]

I'm 50, have been taking 2100mg of choline bitartrate per day experimentally for about a week after reading the MIT study (https://news.mit.edu/2021/study-offers- ... imers-risk) and the Arizona State mouse study (https://onlinelibrary.wiley.com/doi/10.1111/acel.13037). So far no downside to it that I've noticed. It feels like ten shots of espresso straight to the brain except that it doesn't mess with my sleep.

[Jane S]

I'm 50, have been taking 2100mg of choline bitartrate per day experimentally for about a week after reading the MIT study (https://news.mit.edu/2021/study-offers- ... imers-risk) and the Arizona State mouse study (https://onlinelibrary.wiley.com/doi/10.1111/acel.13037). So far no downside to it that I've noticed. It feels like ten shots of espresso straight to the brain except that it doesn't mess with my sleep.

Hello VLB,

Welcome! Thank you for joining our site and posting additional articles to the forum. It's so helpful to see a number of different takes on a topic. And thanks for posting abut your experience with choline. As you go along, I hope you'll continue to share.

As a Support Team Intern, I'd like to welcome you to the forum. I'll share some tools/resources you can use to explore the site, helping you get the most out of your experience.

The Primer is a detailed and informative resource written by a practicing M.D. with ApoE4/4. It includes information about the biochemistry of the ApoE4 gene and offers a variety of research-based prevention strategies.

Some helpful tips to navigate the site include the How-To Guide. It includes topics such as navigating the forum, private messaging, and searching. One great tip is using the quote (") button when replying to a post. Using the button will automatically alert the member of your response.

If you are interested in learning more about other members, you can check out Our Stories.

I'm so glad you joined and look forward to meeting you around the forum. Please feel free to reach out anytime.

Take care.

Jane