I'm happy to give an idea of what was involved for me - I don't think it's proprietary information or anything and I have shared this info with relatives and friends who are also worried about/have a family history of Alzheimer's but were unable to get to see Dr. Isaacson. He really stresses that this is a very individualized process so I'm not sure how much what I did applies to anyone else but it may give some guidance or just be interesting.
Every 6 months I had labs sent to Boston Heart that included a lipid panel (cholesterol, ApoB etc). The exact tests were classified as: Lipid Tests, Lipid Ratios, Boston Heart HDL Map Test, and Boston Heart Cholesterol Balance Test. The main thing I was working towards was Apo B less than 80 and LDL-P less than 1000, which I could usually achieve (generally if I am good about taking my fish oil I can just get my LDL-P or Apo B in that range, sometimes they're just above). My other lipids are mostly in the normal range (I run TG<50 and HDL>60 which is fine so I'm not sure what he's aiming for if you're not in that range). My "absorption markers" tend to be a little off (high) but we didn't really discuss this much.
Other Boston Heart tests were: Metabolic panel (A1C, insulin, C-Peptide etc) all were in range so there was nothing to do there. He also did Inflammatory Tests (CRP, fibrinogen etc) - again, in range for me so I'm not sure what the goal is beyond that.
He also did Boston Heart Fatty Acid Balance Test and would work on getting DHA and EPA in range (whatever the Boston Heart criteria were)
Vitamin D goal was above 50
Homocysteine we didn't discuss much - it was always under 10, sometimes as low as 6. He seemed fine with that.
At my last few visits he suggested doing the Omega Quant test which I ordered online and did. My Omega 3 index was about 10 and he was fine with that (not sure if there's an advantage to any higher than that).
They would also do body composition testing, and occasionally tweak something (mainly emphasizing more strength training and muscle mass, I do a lot of cardio already). My BMI runs about 21 so weight is not an issue.
And there there was about 2 hours of cognitive testing! Nerve-wracking but I guess I'm young enough I would always do fine. I asked once if normal tests in someone my age were actually meaningful since at the time I was about 25 years younger than my mom when she was diagnosed and he said yes, even this far out there can be changes in cognitive testing that signal problems but he didn't see any of this in my testing (it's been a few years now so who knows!)
For supplements he only recommended Omega 3s (Nordic Naturals DHA extra, 4 pills/day which is almost 2000mg DHA/day), Vitamin D 5000IU/day. Sometimes my B12 would be a little low and I would take a B12 supplement. He recommended trying CocoaVia pills or powder but they upset my stomach. Most recently he recommended Theracumin which I take sometimes but again if I take it too often it upsets my stomach. So it's mainly the Omega 3s and Vit D.
I will say I love to exercise and I'm very active (I'm in my 50s and I hike, run, swim, bike, dance and try to do some weight training. I get 12-13,000+ steps every day), and I really try to limit carbs and sugar (only Ezekiel bread, Banza pasta etc), almost no processed food, always take a salad to work for lunch every day, plus I aim for 7-8 cups of vegetables/day. I don't drink any alcohol.
We discussed intermittent fasting - for me he felt 12 hours fasting overnight was fine (thank goodness, because I get grumpy with more fasting).
Oh, at one point when my ApoB/LDL-P crept up a bit we talked about considering Zetia if it didn't come down. But I do find when I am good about taking my fish oil my cholesterol stays in range.
That's pretty much it. Hope it's helpful to someone here!