Why Enhancing Metabolic Health Could be the Key to Preventing Alzheimer's Disease

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TheresaB
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Why Enhancing Metabolic Health Could be the Key to Preventing Alzheimer's Disease

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This video
Why Enhancing Metabolic Health Could be the Key to Preventing Alzheimer's Disease
by neurologist Dr David Perlmutter was posted on the ApoE4.info Facebook page yesterday (Feb 25, 2024) and has attracted a good amount of interest, so I thought I’d share it here.

He starts by reviewing recent Alzheimer's research and pharmaceutical treatments aimed at amyloid plaque removal that have had limited effectiveness with respect to cognitive decline and yet come with potential risks. Then he explores metabolic factors in Alzheimer’s. The video is about a half hour long and easily understandable.

I gleaned the papers (but not the articles) that he cites in the video and list them below if anyone is interested in researching beyond the highlights he presented:


Lecanemab in Early Alzheimer’s disease
Christopher H van Dyke M.D. et al
5 Jan 2023
New England Journal of Medicine
https://www.nejm.org/doi/10.1056/NEJMoa2212948


Detection and Management of Amyloid-Related Imaging Abnormalities in Patients with Alzheimer’s Disease Treated with Anti-Amyloid Beta Therapy
Jerome Barakos et al
2 Feb 2022
The Journal of Prevention of Alzheimer's Disease
https://link.springer.com/article/10.14283/jpad.2022.21


Accelerated Brain Volume Loss Caused by Anti–β-Amyloid Drugs A Systematic Review and Meta-analysis
Francesca Alves, BBMED(Hons), PhD et al
27 Mar 2023
Neurology
https://www.neurology.org/doi/abs/10.12 ... 0000207156


Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease
Randall J. Bateman, M.D. et al
16 Nov 2023
New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJMoa2304430


In Alzheimer Research, Glucose Metabolism Moves to Center Stage
Bridget M. Kuehn, MSJ
8 Jan 2020
JAMA
https://jamanetwork.com/journals/jama/a ... ct/2758712


Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study
Jianping Jia, professor
25 Jan 2023
BMJ
https://www.bmj.com/content/380/bmj-202 ... 5TTbDz-hd4


Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
Stephanie Kullmann
22 Sep 2022
JCIinsight
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675563/


Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK
Borja del Pozo Cruz, PhD, et al
6 Sep 2022
JAMA
https://jamanetwork.com/journals/jamane ... ct/2795819


Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease
Massimo Venturelli et al
13 Mar 2018
Frontiers in Physiology
https://www.frontiersin.org/journals/ph ... 00169/full
-Theresa
ApoE 4/4
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