Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

[laurie]

August 2024 update. I have started a You Tube channel and my most recent video is on APOE 4 and why this allele increases your risk of Alzheimer's. I was motivated to make this video because of the many 'stories' from people who learn they have ApoE 4 and are so fearful. I can understand the fear however I want to provide people with information which will substantially reduce their fear. Alzheimer's can be prevented !

Here is a link https://www.youtube.com/watch?v=Q_Td6A4XuNE&t=1s

My video's are evidence based. Here are some of the studies presented in my ApoeE 4 video: Montagne, A., et al.; APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline; Nature; May; 581(7806:71-6 (2020) Drago, D., et al.; Potential pathological role of B-amyloid1-42-aluminum complex in Alzheimer’s disease; Int. J. Biochem. Cell Biol.; 40:731-46 (2008) Wang, Y., et al.; Effect of aluminum combined with ApoE E4 on tau phosphorylation and AB deposition; J. Trace Elem. Med. Biol.; March; 64:126700 (2021) Hashimoto, T., et al.; Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid B peptide; Oct.; J. Neurosci.; 32(43):15181-92 (2012)

Link to Wang paper https://www.sciencedirect.com/science/a ... via%3Dihub

Link to Hasimoto paper https://www.jneurosci.org/content/32/43/15181

Here is a preview: Weakened Blood Brain Barrier, High Beta amyloid accumulation resulting in more oligomers which are more toxic (Apoe4 have 2.7 more oligomers compared to APOE 3), APOE4 plus aluminum - 2 factors interact with each other and show a synergistic effect (produce a combined effect greater that the sum of their separate parts). Keep drinking your silica water and avoid aluminum !

[barbS]

August 2024 update. I have started a You Tube channel and my most recent video is on APOE 4 and why this allele increases your risk of Alzheimer's. I was motivated to make this video because of the many 'stories' from people who learn they have ApoE 4 and are so fearful. I can understand the fear however I want to provide people with information which will substantially reduce their fear. Alzheimer's can be prevented !

Here is a link https://www.youtube.com/watch?v=Q_Td6A4XuNE&t=1s

My video's are evidence based. Here are some of the studies presented in my ApoeE 4 video: Montagne, A., et al.; APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline; Nature; May; 581(7806:71-6 (2020) Drago, D., et al.; Potential pathological role of B-amyloid1-42-aluminum complex in Alzheimer’s disease; Int. J. Biochem. Cell Biol.; 40:731-46 (2008) Wang, Y., et al.; Effect of aluminum combined with ApoE E4 on tau phosphorylation and AB deposition; J. Trace Elem. Med. Biol.; March; 64:126700 (2021) Hashimoto, T., et al.; Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid B peptide; Oct.; J. Neurosci.; 32(43):15181-92 (2012)

Link to Wang paper https://www.sciencedirect.com/science/a ... via%3Dihub

Link to Hasimoto paper https://www.jneurosci.org/content/32/43/15181

Here is a preview: Weakened Blood Brain Barrier, High Beta amyloid accumulation resulting in more oligomers which are more toxic (Apoe4 have 2.7 more oligomers compared to APOE 3), APOE4 plus aluminum - 2 factors interact with each other and show a synergistic effect (produce a combined effect greater that the sum of their separate parts). Keep drinking your silica water and avoid aluminum !

hello laurie - I followed Dr. Crouse and his suggestions, as well. In my "arsenal" against aluminum, I have THREE different water filters taking care of that, with my addition of liquid silica drops, as well as trace minerals. (maybe some pure stream salt).
I am a do it myselfer.
I have not had an actual md visit since a kidney stone emergency in 2017. Before that it had been awhile.
So far, i am apoe3/4 with a couple snps that do NOT help in the way nutritionally - as if the cards are stacked against me no matter what I try.
(I did 23andme test, I watched Dr. Bredensens vids, have his book, along with many just for info and what NOT to do).

I recently found news about the blood test for Tau p - 217, and cannot afford at this time. My question is -

What does one do differently with results?

Sigh relief -when low- and carry on? whew! ... the course of action if it is NOT low? (Working with doctors may be helpful, as far as pharmaceuticals go - MORE tests? )

But what is the plan? More exercise? Piano classes? Learn to speak French?

This is the area I find most disheartening. What is the post p - Tau 217 test plan? The course of action? I cannot find any of the "treatments" in any of the literature, sites, etc I have been looking thru for days. Nothing. Just... "treatments" huh? there are treatments? Can one just jump to a treatment without the cost of another test?

I am overjoyed testing has found a way to measure - a baseline, as it were. But - then what? What does one do after? If low? if HIGH?
I am very happy with my going FULL ON organic many years ago, Gluten free, filtered water or Volvic, supplements, etc. Increased my participation in MIND saving after 23andme pushed me into the apoe3/4 arena.
-- Now there is a test.
Wish I would love to participate in - but what happens with that knowledge? what, if anything, begins anew?
Can a 3/4 just skip the test and go straight to the "treatments" ? I am not having serious events. Just some hmmm moments when my daughter begins with "mom, do you remember that time..." sort of issues.

I try just about any/everything. I have the 40hz light, audio. Photobiomodulation lamps. Air filters. Toxin free home. My wave plate for circulation and balance, walk walk walk some more. DIET!!! Many supplements that take up two entire shelves in my kitchen cabs. Diet is so important, but I stopped processed years before THE TEST and bumped up the quality with wild caught salmon I am committed to staying healthy for another 60 years.

My most current big spend on tests was cardio related. Scan. No blockage even beginning. whew. All is well there for being 68. (And was offered a plan for $2500 to keep an eye on things... ) My immediate family runs away - no tests for them. Parents were not healthy, but brains were on task. They fell victim to life style choices: alcohol, smoking, etc.



Thank you.

[laurie]

Hi barbS,

Thank you for your thoughts/questions. Thank you also for your interest in the information my husband has written about.

You mention P Tau 217 and the high cost of a test. It is unfortunate there isn't an affordable test to see if a person has preclinical signs of Alzheimer's. However a test for P Tau 217 is not the best test when looking for preclinical signs of AD. Here is a quote from Dennis' most recent book. "CSF p-tau231 is quicker than CSF p-tau181 or CSF p–tau217 in signaling early-stage preclinical sporadic AD, even when AB pathology is too subtle to be detected (see figure 21)126." You may want to read this paper 126. Suarez-Calvet, M., et al.; Novel tau biomarkers phosphorylated at T181, T217, or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Ab pathology are detected; EMBO Mol. Med.; 12:e12921 (2020) Rungs 9 - 13 in Dennis' most recent book present research about Tau and aluminum.

You may want to consider doing a 24 hour urine test for aluminum. In the US, request a test charges $99 for this test. It is not available in all states. Here is a link to a write up about this test. https://prevent-alzheimers-autism-strok ... rcury.html

I see you are 68 and APOE 3/4. I am 69 and APOE 3/4. Let me tell you why I feel confident I will not get Alzheimer's. From Dennis's research I have learned aluminum is the cause of Alzheimer's. I have done two 24 hour urine tests and my aluminum level on the last test in 2023 is that of a 20 year old. My low aluminum levels make me confident I will not get Alzheimer's. Here is a write with more detail about my testing results. Although I did not have any noticeable cognitive issues prior to drinking silica water and eliminating sources of aluminum my cognition has improved. My brain is faster and sharper and both my short term and long term memory have improved. https://prevent-alzheimers-autism-strok ... ced-by-40/

You say you are using "silica drops" - this will not provide you with enough of the form of silica (OSA) needed to remove aluminum. My husband has tested the drops. Mineral water is the only source that has enough OSA to remove aluminum. You say you are using 3 water filters. If you are using a filter that removes fluoride make sure is does not use aluminum oxide to remove the fluoride. Be careful with adding trace minerals to your water as some can contain aluminum. Ones from the Great Salt Lake have aluminum.

Laurie