Hello, i did a MyHeritage test!

[Nathanwales]

[img]Hello, 29 year old here.
I recently did a MyHeritage test and i got positive on 2 results:

APOE - rs429358(C;T). (cys112arg)
Pathogene variant
25,22% frequent

APOE - rs7412(C;C). (arg158cys)
Typical variant.
85,38% frequent


I have tried to look online but i cant find an answer. Nor do i have any idea what it all means.
I was hoping someone could help me out and explain it to me. And tell me where i fall in the risk factor.

Thank you!

[Tincup]

I have tried to look online but i cant find an answer. Nor do i have any idea what it all means.
I was hoping someone could help me out and explain it to me. And tell me where i fall in the risk factor.

Hi Nathan,

Welcome!

See this table from Snpedia:

Code: Select all

rs429358	rs7412			Name
C		T			ε1
T		T			ε2
T		C			ε3
C		C			ε4

{edit}
APOE - rs429358(C;T)
APOE - rs7412(C;C)

Reorganizing, taking the first letter (C) from rs429358 and the first letter (C) from rs7412 gives a (C/C) for one SNP (single nucleotide protein). Doing the same for the second letters gives (T/C). You got one of these pairs from each parent (and if you have children or have them in the future, each child will have a 50% chance of inheriting an ε4 from you).
{end edit}

As you can see, a T/C is ε3, and a C/C is ε4.

So an ApoE 3/4. Some others here have posted on the latest thought on risks. Here is one. Remember, the biggest risk for dementia is age itself. ApoE4 can accelerate that risk. Even 2/2's, which have the lowest risk, have a non zero one.

[Nathanwales]

I have tried to look online but i cant find an answer. Nor do i have any idea what it all means.
I was hoping someone could help me out and explain it to me. And tell me where i fall in the risk factor.

Hi Nathan,

Welcome!

See this table from Snpedia:

Code: Select all

rs429358	rs7412			Name
C		T			ε1
T		T			ε2
T		C			ε3
C		C			ε4

{edit}
APOE - rs429358(C;T)
APOE - rs7412(C;C)

Reorganizing, taking the first letter (C) from rs429358 and the first letter (C) from rs7412 gives a (C/C) for one SNP (single nucleotide protein). Doing the same for the second letters gives (T/C). You got one of these pairs from each parent (and if you have children or have them in the future, each child will have a 50% chance of inheriting an ε4 from you).
{end edit}

As you can see, a T/C is ε3, and a C/C is ε4.

So an ApoE 3/4. Some others here have posted on the latest thought on risks. Here is one. Remember, the biggest risk for dementia is age itself. ApoE4 can accelerate that risk. Even 2/2's, which have the lowest risk, have a non zero one.

Is C more dominant than T?

And i get that by doing the second letter you get T/C. But thats only if you start with the second letter of rs429. If you do it the other way around its C/T.

Can you maybe elaborate more on how the genes work?

And about the apoe 3/4? I thank you already for helping me and giving me the stuff to read.

But by my understanding im 3/4 since i have 3C’s and 1 T?

And wich of those do i have a 50% chance to pass onto my kids? Isnt the rs429 more dangerous than the rs74

[Andrea Hamilton]

Hi Nathan,

I am a support intern here at APOe4 and I too would like to welcome you to the site. I applaud your curiosity and self-advocacy in learning as much as you can about your MyHeritage results. This site is a source of a great deal of information and inspiration, and a great starting place!

I'm glad that Tincup has been able to let you know that you have ApoE 3/4. But here's another chart from Snpedia that might clarify things. In it you can see how your two genes combine in the second last row to make you ApoE 3/4. What you have is one copy of ApoE3 and one copy of ApoE4. You got the ApoE3 from one parent and the ApoE4 from the other. You, just like your parents, will pass on one of those to each child you may have. So it is a 50/50 chance of passing on a 3 or passing on a 4 to each child.

Snpedia chart of ApoE combinations.jpeg

About 25% of people worldwide are also ApoE 3/4. As far as risk goes, in large population studies of people your grandparents' age with ApoE 3/4, the risk by age 85 of mild cognitive impairment or Alzheimer's dementia may be about 20%, with most of that risk after age 75. The great news is, for your generation, with more knowledge of healthy lifestyles and more research on ApoE4 prevention, it's certain to be far less.

If you haven't already found it in the link that Tincup provided, I can provide some guidance to using the site here. The How-To Guide includes topics such as navigating the forum, private messaging, and searching.

A great place to start is the Primer , a detailed and informative resource written by a practicing M.D. with ApoE4/4.

I'm so glad you have joined us on this site. At your age you have a great deal of control over your health outcomes and this site can be immensely helpful in ensuring those are the best they can be!

Please feel free to ask any questions you might have.

In health,
Andrea Hamilton

[Tincup]

Is C more dominant than T?

And i get that by doing the second letter you get T/C. But thats only if you start with the second letter of rs429. If you do it the other way around its C/T.

You get one rs429358 and one rs7412 from each parent.

The table I quoted is ordered such that rs429358 is first, but there is not a significance to this I'm aware of.

Your data, as you listed:
APOE - rs429358(C;T)
APOE - rs7412(C;C)

(C;T) rs429358
(C;C) rs7412

Above I just put the rs tags last, so the data for each stack above one another. Then to get one SNP you pick the first (left) one from rs239358 and then go down to the letter below it from rs7412 to get a a (C:C) pair from (rs429358;rs7412). Then you repeat to with next letter, T, and get (T;C) to get the next SNP. So there is one (rs429358;rs7412) pair from each parent.

Hope that makes more sense.

[TheresaB]

I have tried to look online but i cant find an answer. Nor do i have any idea what it all means.
I was hoping someone could help me out and explain it to me. And tell me where i fall in the risk factor.

APOE is a gene that comes with different variations called alleles. The alleles are APOE2, APOE3 and APOE4.

One allele comes from mom, the other from dad, so the possiblities are APOE 2/2, or 2/3, or 2/4, or 3/3, or 3/4, or 4/4.

You happen to be APOE 3/4. The 4 represents an elevated risk for Alzheimer's. The 4 is a strong influencer of things going on it the body, but it doesn't mean you will inevitably get Alzheimer's some day. Since the 4 is the oldest by far of the three alleles, it doesn't seem to be having an easy time adjusting to the modern, western lifestyle and diet, it still "thinks" its living in a hunter-gatherer.

Lifestyle factors can make a significant difference in reducing risk. Endeavor to be extra diligent in lifestyle choices to decelerate the aging process in order to maximize your chances of living a long, healthy, cognitively intact life. These lifestyle choices consist mostly of diet (including timing of feeding to allow the body a chance to work on other processes besides digestion), leading a non-sedendary life, honoring circadian rhythm with a concentration on sleep hygiene, and avoiding chronic stress.

Best to you in your health journey.

[Nathanwales]

Thanks so much everyone for the help!
Very clear and easy to follow explanation.

I will try to look at all your links and get the rest of the details and knowledge myself.

I wish you all the best.