do ozempic and GLP-1s reduce APOE4 brain fog?

[shenmen100]

I have been "microdosing" Tirzepatide ( generic Monjero) for 10 weeks at a dose of 1 mg a week. Normal starting dose is 2.5 mg but since I am not insulin resistant it worked right away with appetite suppression. I have lost 10 lbs that I needed to lose so now I will slowly wean down to a base dose where I do not lose weight and stay there to assess its affects. It is too early to notice any brain changes except appetite, but I am taking it more as a preventative for now. I was getting the Tirzepatide from a research lab in the US, but Eli Lilly just sent out cease and desist letters directly to the labs so it is no longer available, BUT Semiglutide (generic Ozempic) is still available. Here is one of the research labs I use.
https://www.peptidesciences.com/

[CAngelS]

If you use a service like tryeden or Ro or hims or one of many others, they send you a bottle and needles and you inject yourself. very simple.

Thanks for the advice. Are TryEden, Hims, &/or Ro stand-alone or something you use in addition to IndiaMart?

[nunchers]

Those are standalone-- IndiaMart was how I got the oral semaglutide but I think the injection is way better so I suggest using one of those sites to get an injectible instead.

[CAngelS]

Thanks!

[Brian4]

Has anyone dug into the literature to see whether weight loss was controlled for in any of these studies?

Ideally, there would be a study that had an arm with people dieting to match the weight that was lost in the arm with the GLP-1 receptor agonists. The people in that dieting arm might see the same improvements – or better – in brain health.

The consequence of such a finding would of course be very important: lose weight by cheaper and more tried and true means, and you’ll get the same benefits.

Of course, if it’s hard to lose weight without GLP-1 receptor agonists, then no shame in using them!

Note: here's a systematic review that did not show huge benefits of GLP-1 receptor agonists on brain health:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091751/

Brian

[Orangeblossom]

I've recently started on 2.5mg mounjaro for weight and noticing some less anxiety and depression, it is early days but I will see how it goes with memory etc. have lost 2kgs already but that is Ok I needed to

[shug]

Does anyone know the dose they used in alzheimer's studies using ozempic? I am borderline diabetic and did a trial with ozempic but vomited nonstop. I have played with smaller doses to prevent the nausea but I'm not sure if it would be enough to help with alzheimers...

[NF52]

Does anyone know the dose they used in alzheimer's studies using ozempic? I am borderline diabetic and did a trial with ozempic but vomited nonstop. I have played with smaller doses to prevent the nausea but I'm not sure if it would be enough to help with alzheimers...

Here's an excerpt from AAIC2024 on one trial that got attention:

Evaluating the Effects of the Novel GLP-1 Analogue Liraglutide in Alzheimer’s Disease (ELAD) ... included 204 patients with mild Alzheimer’s disease seen at 24 clinics throughout the United Kingdom. Each received a daily subcutaneous injection for one year: half (102) received up to 1.8 mg of liraglutide and half (102) received a placebo. Before the study began, all patients had magnetic resonance imaging (MRI) to evaluate brain structure and volumes, glucose metabolism PET scans and detailed memory testing. These were repeated at the end of the study with regular safety visits.

https://aaic.alz.org/releases-2024/glp- ... mentia.asp

That's a different drug, but WAY above the recommended starting weekly dose of 0.25 mg on ozempic, from this source:https://www.verywellhealth.com/ozempic- ... se-8640189 But these are people who were in the mild stage of Alzheimer's dementia, with significant neuronal changes. It's reasonable that they would need a far higher dose to find benefit.

In the AHEAD-45 study of people with normal cognition and amyloid PET levels ≥ 40 centiloids, those on the lecanemab arm got 2 years of biweekly doses, twice the "dose" of those in AHEAD-3 with amyloid PET levels ≥20 and <40 centiloids. Dr. Reisa Sperling, co-lead of AHEAD, spoke at AAIC24 and said she and other researchers envision what would be the equivalent of micro-dosing, with maybe semi-annual dosing in the earliest preclinical stages, if memory serves.

The benefits of GLP-1 in people with normal cognition are not yet known, nor are any safety risks or effective doses. I'm sorry to hear that you had what I would view as a serious adverse effect.

Nancy

[shug]

Thank you, Nancy!