Top articles / recent research & helpful thoughts for ApoE4s

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
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TheresaB
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Re: Top articles / recent research & helpful thoughts for ApoE4s

Post by TheresaB »

3rd quarter 2024

In addition to this website, we (ApoE4.info) have a Facebook page https://www.facebook.com/apoe4.info followed by thousands where current research/articles or just thoughts of interest to ApoE4s are posted. The posts are available to all whether or not a person has a Facebook account.

Here are the Facebook posts/papers that generated the most interest during the third quarter (July - Sept) of 2024 in order of popularity.

Reminder: You must be logged into this site to see the graphics posted, but the links to the articles/papers/videos are accessible without logging in.

Date posted: Aug 25, 2024
24_08_25 Markers of inflammation.jpg
Facebook comment:
None


Date posted: Sep 27, 2024
Link to article/paper posted:
A Holy Grail for ApoE4?
https://www.apollohealthco.com/a-holy-g ... 8cGLChvZug
Facebook comment:
The Drug Discovery Lab at UCLA designed a drug candidate that is orally bioavailable, potent, brain penetrating, and highly effective at restoring the DNA activity that is otherwise blocked by ApoE4. This drug candidate could be taken for prevention as well as for treatment. To date, this candidate has shown no evidence of toxicity, and appears to be a superb prospect for human trials.


Date posted: Sep 3, 2024
Link to article/paper posted:
These 4 Neuroprotective Nutrients Can Help Reduce Your Dementia Risk
https://www.mindbodygreen.com/articles/ ... apgu_XH9tw
Facebook comment:
While genetics can play a role in the development of dementia, the risk of dementia doubles every five years after the age of 65. So It's never too early—or too late—to start protecting your brain and optimizing it for cognitive longevity.
This article breaks down four brain-critical nutrients you should be getting daily to help protect against dementia


Date posted: Jul 2, 2024
Link to article/paper posted:
The Great Cholesterol Scam and The Dangers of Statins
https://www.midwesterndoctor.com/p/the- ... _RmO888w5A
Facebook comment:
As hyperabsorbers, ApoE4s tend to have high cholesterol numbers and doctors often prescribe statins without even knowing a person’s APOE status. The author of this article is undisclosed and is only identified as a Midwestern Doctor, so take that for what it’s worth. Nevertheless, this is an interesting article with many things to consider in exploring causes of heart disease, injurious concerns associated with statins, and the authors preferred treatments. We’d like to hear your thoughts on this article or if you have any information on the author.


Date posted: Sept 25, 2024
24_09_25 Bredesen 7 for neuroplasticity.jpg
Facebook comment:
The Bredesen 7 for neuroplasticity : Nutrition, Exercise, Sleep, Stress, Stimulation, Detox, Supplements.
To learn more, visit Dr Bredesen’s Apollo Health website https://www.apollohealthco.com/


Date posted: Jul 7, 2024
24_07_07 inflamm-aging.jpg
Facebook comment:
Research suggests that inflamm-aging may be why we’re more likely to develop health conditions as we get older.
Acute inflammation is vital for the body’s healing process. However, chronic inflammation can trigger a variety of common diseases that appear as we get older, including Alzheimer’s disease, arthritis, cancer, heart disease, and type 2 diabetes.
By managing chronic inflammation with healthy lifestyle habits, you may avoid or slow the progression of inflammation-related chronic conditions.


Date posted: Jul 15, 2024
24_07_15 cognitive impairment fm lifelong events.jpg
Facebook comment:
You can't change the past, but the brain is plastic, which means the brain has a unique ability to change, and today is the first day of the rest of your life.


Date posted: Aug 2, 2024
Link to article/paper posted:
Vegan diet may slow aging
https://www.news-medical.net/news/20240 ... cgmmHrFHTw
Facebook comment:
ApoE4s don’t seem to age as well as our non-carrier brethren. A recent BMC Medicine study investigated whether vegan and omnivorous diets differentially impact an individual's epigenetic clock.
The current single-site, randomized, and parallel-group dietary intervention trial compared the effects of healthy vegan and omnivorous diets by analyzing blood DNA methylation patterns, age-related risk factors, and health biomarkers in healthy twins.


Date posted: Jul 2, 2024
Link to article/paper posted:
The Path Bill Gates Sees to Overcoming Alzheimer’s Biggest Remaining Challenges
https://www.scientificamerican.com/cust ... 2bjy7RsMOg
Facebook comment:
Much of the wealth Bill Gates has amassed as founder of Microsoft has gone to charity.
Gates has focused his philanthropy largely on some of the most intractable health problems, such as malaria, HIV/AIDS and childhood vaccination. In recent years, he has turned to Alzheimer’s disease, starting with diagnostics and more recently expanding to proteomics and healthcare programs related to the disease.


Date posted: Aug 15, 2024
Link to article/paper posted:
Significant link found between heme iron, found in red meat and other animal products, and type 2 diabetes risk
https://medicalxpress.com/news/2024-08- ... PSfwuB4OpQ
Facebook comment:
We’ve posted repeatedly on the importance for ApoE4s to maintain insulin sensitivity. Type 2 Diabetes is insulin resistance at its final progression. While the paper discussed in this article has limitations, the paper found higher intake of heme iron, the type found in red meat and other animal products was associated with a higher risk of developing type 2 diabetes. This connection has been reported previously, but this study's findings more clearly establish and explain the link.


Date posted: Aug 24, 2024
Link to article/paper posted:
Microplastics are infiltrating brain tissue, studies show: ‘There’s nowhere left untouched’
https://www.theguardian.com/environment ... heuWCDaOBQ
Facebook comment:
Twenty-four brain samples collected in early 2024 measured on average about 0.5% plastic by weight.


Date posted: Sep 8, 2024
Link to article/paper posted:
4 Benefits Of Regular Sauna Use, From Brain Health To Longevity
https://www.mindbodygreen.com/articles/ ... HSyvDjOo3k
Facebook comment:
Both neurologist Dale Bredesen, M.D., author of "The End of Alzheimer's", and energy specialist Ari Whitten, author of "Eat for Energy", sing the praises of the mighty sauna.


Date posted: Jul 31, 2024
24_07_31 Thomas Edison on doctor of the future.jpg
Facebook comment:
The famous inventor Thomas Edison said this quote in 1903, over 100 years ago. While there's been some progress in this area, this quote could have easily been from yesterday.


Date posted: Aug 23, 2024
Link to article/paper posted:
The Best Time to Take Omega-3s for Maximum Absorption, According to Experts
https://www.eatingwell.com/best-time-to ... nt-8698419
Facebook comment:
Omega-3s are important for brain health and evidence is mounting that E4 carriers need more Omega-3s than non-carriers. This article addresses how to optimize Omega-3 supplements. Of note, there’s a small population of ApoE4s that should stick with obtaining their Omega-3s via fish consumption, not supplementation (just stay away from large fish, since they are at the top of the food chain, they have the highest levels of the neurotoxin mercury). If you have a male relative who suffered a stroke, be suspicious that it may have been Cerebral Amyloid Angiopathy (CAA), which ApoE4s are at greater risk for. So ApoE4 carriers (especially males) with male family history of stroke, may want to avoid fish oil supplements since it thins the blood. Same caution with any medication that thins the blood.
Link to article/paper posted:


ALSO, just published and added to the ApoE4.info Wiki in the last quarter:

35 just published items that specifically address ApoE4 can be found in the ApoE4.info wiki: A deeper dive into ApoE4

Alcohol consumption
• podcast #92 The Truth About Alcohol: Risks, Benefits, and Everything In-Between | Dr. Rhonda Patrick posted 2 July 2024

ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s
Herpes zoster and long-term risk of subjective cognitive decline (Tian-Shin Yeh et al, 14 August 2024)

Beneficial (and some negative) Plant/Natural Chemicals
Exploring the Role of Reactive Oxygen Species in the Pathogenesis and Pathophysiology of Alzheimer’s and Parkinson’s Disease and the Efficacy of Antioxidant Treatment (Talin Gogna et al, 20 Sept 2024)
Plant Extracts as Emerging Modulators of Neuroinflammation and Immune Receptors in Alzheimer's Pathogenesis (Intisar E. Mohamed et al, 10 Aug 2024)
Platycodon grandiflorum root extract inhibits Aβ deposition by breaking the vicious circle linking oxidative stress and neuroinflammation in Alzheimer’s disease (Yunkwon Nam et al, August 2024)

Cannabinoids: CBD, CBN, CBG, THC etc. Also HEMP & Marijuana (Cannabis)
Cannabidiol, a plant-derived compound, is an emerging strategy for treating cognitive impairments: comprehensive review of randomized trials (Adriana Yndart Arias et al, 10 September 2024)
Acute effects of cannabigerol on anxiety, stress, and mood: a double-blind, placebo-controlled, crossover, field trial (Carrie Cuttler et al, 13 July 2024)

Circadian Rhythm
Circadian rhythms in cardiovascular (dys)function: approaches for future therapeutics (Margaux Lecacheur et al, 23 Sep 2024)

Exercise - Types, Lengths, and Benefits
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training (Daniel G. Blackmore et al, 8 Jul 2024)
Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats (Sarah Nicolas et al, 24 April 2024)

Fats, Omega -3(ω-3) & -6(ω-6), DHA and More
ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults A Randomized Clinical Trial (Lynne H. Shinto et al, 1 Aug 2024)

Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs)
• YouTube presentation: Targeting Gut Dysbiosis in APOE4 Carriers Strategies for Mitigating Alzheimer's Disease Risk & summary slide
The Gut Microbiome-Neuroglia Axis: Implications for Brain Health, Inflammation, and Disease (Josué Camberos-Barraza et al, 1 Aug 2024)
Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation: results from two observational, population-based microbiome studies (Robert F J Kullberg et al, 20 June 2024)

Insulin Resistance
Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk (Fenglei Wang et al, 13 Aug 2024)

Non-white or non-European descent
Epidemiology and prevalence of dementia and Alzheimer's disease in American Indians: Data from the Strong Heart Study (Astrid M. Suchy-Dicey, 15 May 2024)

Resveratrol
Exploring resveratrol against Alzheimer’s disease and Parkinson’s disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vitro (Jinpu Wu et al, 13 Sep 2024)

Sleep
Sleep, 24-Hour Activity Rhythms, and Subsequent Amyloid-β Pathology (Phuong Thuy Nguyen Ho et al, 24 Jun 2024)
Sleep duration, chronotype, health and lifestyle factors affect cognition: a UK Biobank cross-sectional study (Raha West et al, 10 Jul 2024)
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-Theresa
ApoE 4/4
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