High P-Tau 217 Results on Brainscan

[Anny]

Hello Everyone,

Thank you to members of this board. Your intelligent discussions inspire me and give me hope. I am new to this board. I am a ApoE4 heterozygote. I have exceeding strong family history of AD (includes grandmother, one aunt, one uncle, and 2 cousins with AD). Since it runs so strongly in my family, I decided to get tested for ApoE4 and as I stated I'm a 3/4. I'm also wondering, if we have other genes that our contributes to such a strong streak of dementia in our family. I have known about my gene since 2017 and have been on Precode for 3 years.

I am 71 years old, female, on HRT, and pretty darn healthy. I exercise more than recommended - quite a bit of uphill walking 5 times a week, maybe 4 miles to 6 miles. I also lift weights a couple times a week. My neuroquant test was done recently and it was 75. So cognition is fine.

I opted to do the Brainscan and I have the P-Tau 217 pathology. It came out .94 ng/l. which seems pretty high - normal high cutoff is .47 ng/l. However, GFAP and NFIL is quite good low. I'm struggling to know and understand my results. If I am on Precode - why do I have high P-Tau?

So Bredesen's message is if you get a P-Tau 217 you double down and do Recode. My question to you knowledgeable ApoE4.info members - is this. Are there NIH studies that tract P-tau 217 and show it going down with certain lifestyle interventions? I have a high amount of P-Tau 217 and I am already pretty committed to the Brenden 7. What is the evidence that P-Tau 217 goes down with lifestyle interventions? I feel I'm already committed to the Bredesen lifestyle so I don't know what to do.

Are there those on this board that have had Pet scans and know they have the AD pathology but have normal cognition? What are you doing to bring your P-Tau 217 down? Is it possible to have the P-Tau 217 deposits/blood levels pathology without ever losing your cognition?

Thank you for any thoughtful answers.

Anny

[Laurie Sotro]

Hello Everyone,

Thank you to members of this board. Your intelligent discussions inspire me and give me hope. I am new to this board. I am a ApoE4 heterozygote. I have exceeding strong family history of AD (includes grandmother, one aunt, one uncle, and 2 cousins with AD). Since it runs so strongly in my family, I decided to get tested for ApoE4 and as I stated I'm a 3/4. I'm also wondering, if we have other genes that our contributes to such a strong streak of dementia in our family. I have known about my gene since 2017 and have been on Precode for 3 years.

I am 71 years old, female, on HRT, and pretty darn healthy. I exercise more than recommended - quite a bit of uphill walking 5 times a week, maybe 4 miles to 6 miles. I also lift weights a couple times a week. My neuroquant test was done recently and it was 75. So cognition is fine.

I opted to do the Brainscan and I have the P-Tau 217 pathology. It came out .94 ng/l. which seems pretty high - normal high cutoff is .47 ng/l. However, GFAP and NFIL is quite good low. I'm struggling to know and understand my results. If I am on Precode - why do I have high P-Tau?

So Bredesen's message is if you get a P-Tau 217 you double down and do Recode. My question to you knowledgeable ApoE4.info members - is this. Are there NIH studies that tract P-tau 217 and show it going down with certain lifestyle interventions? I have a high amount of P-Tau 217 and I am already pretty committed to the Brenden 7. What is the evidence that P-Tau 217 goes down with lifestyle interventions? I feel I'm already committed to the Bredesen lifestyle so I don't know what to do.

Are there those on this board that have had Pet scans and know they have the AD pathology but have normal cognition? What are you doing to bring your P-Tau 217 down? Is it possible to have the P-Tau 217 deposits/blood levels pathology without ever losing your cognition?

Thank you for any thoughtful answers.

Anny

Hello Anny,

My name is Laurie and as a Support Team Intern, I would like to welcome you to this forum; we are so glad you joined us! You have found a very supportive and encouraging community here.

Thank you for sharing your information with us. I commend you for your strength and resilience! What a go-getter you are! I also commend you for your engagement and dedication with the Bredesen Protocol. By sharing this you are an inspiration to others here who will read and be motivated by your post. Even though you may be a new member to our community, you are already setting an amazing example!

I love that you’ve asked others to share their knowledge with you, and I’m sure so many will.
Regarding the p-tau blood test, it predicts, but does not guarantee, that a person would have some amyloid plaques if they had a PET scan, but that amyloid plaques can occur without any cognitive issues, since several members of the forum have them and are in clinical trials for people with normal cognition. The goal of Dr. Bredesen’s program is to identify and support measures that could prevent, reduce, delay and/or treat symptoms of cognitive or other changes in everyday life. Biomarkers like amyloid appear to have many causes and to develop very slowly for up to 20 years before they are measurable. So it’s likely that everything you are doing for your brain and overall health is giving you “cognitive resilience”. And I’d call that a definite win-win! Great job Anny!!

For some ideas to help support you on your continued health journey, you may want to take a look at some of our resources; here are a few links to help get you started and become more familiar with our site.

The How-To Guide will help you learn how to navigate this site. It includes topics such as navigating the forum, private messaging, and searching.

If you haven't already, it would be a great idea to also take a look at our Primer. It is an incredible resource of information about the biochemistry of ApoE4. It offers researched-based prevention strategies and was written by a practicing M.D. with ApoE4.

We would love to hear more of your own story, and what brought you to this site, when you feel comfortable. You can post that as a reply here, or in the "Our Stories" section. You might want to read through other members' experiences in Our Stories. Sometimes reading the stories of others helps us realize that we are not alone.

I know you will find the information and support you need from this community! Please reach out if you have any questions!

Kindly,
Laurie Sotro