Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

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J11
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

Post by J11 »

This patient report is pretty close to a cancer cure for a terminal patient.

http://link.springer.com/article/10.100 ... 012-9417-4

http://link.springer.com/journal/10863/44/1/page/1

This report is also extremely impressive. 2 combination doses of 3-Bromopyruvate with acetaminophen
resulted in a metabolic cure of an extreme cancer burden.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110469/
rep
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

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Wow! If we can take this at face value I don't understand why it hasn't gotten more press.
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

Post by rep »

I found this on a thread (http://pipeline.corante.com/archives/20 ... is_odd.php) questioning the funding of TaoRx. Turns out the person names Liz is TaoRx's media person.
I would like to hear more from Liz on the link between tau tangles and Alzheimer's disease. Does tau hyperphosphorylation interfere with neurotransmissions and/or is it something else?

I agree with Liz that it is foolish to focus on amyloid plaques after so many failed trials. And it is not a matter of just starting earlier. Some of the finidings regarding amyloid plaques is that they are not toxic in themselves,that the transition metals in amyloid plaques damage but do not kill neurons, and that the chelation of metals out of plaques does not stop the peroxynitrite-mediated killing of neurons. Amyloid plaques are both a symptom and partially cause of Alzheimer's disease but not the main cause (the main cause is likely the p38 MAPK generation of peroxynitrites).

What can be said of amyloid plaques can also be said of hyperphosphorylated tau proteins, though. Not only do peroxynitrites through the oxidation of g-protein coupled receptors and nitration of tyrosine kinase receptors contribute to the hyperphosphorylation of tau proteins they also mediate the nitration of tau proteins themseleves which prevents them from being reconstituted (just as the peroxynitrite-mediated nitration of amyloid plaques contributes to their aggregation and limits their clearance).

http://www.ncbi.nlm.nih.gov/pubmed/16816118
http://www.ncbi.nlm.nih.gov/pubmed/21903077

As far as I know targeting tau tangles, does nothing to stop the peroxynitrite-mediated nitration of NMDA receptors which results in the efflux of glutamate which causes inflammation or the influx of calcium which kills neurons. Nor does it reverse the oxidation of g-protein coupled receptors involved in sleep, mood, alertness, smell, social recognition, and short-term memory.

Tau tangles are probably a more important target than amyloid plaques but this does not address the totality of the disease. Peroxynitrite scavengers do.
J11
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

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https://www.facebook.com/TheCancerCure

http://www.dayspringcancerclinic.com/3- ... er-clinic/

http://www.longecity.org/forum/topic/73 ... ncer-cure/

3-BP has patent troubles. It is used on an industrial scale as a fungicide and is sold on the internet by Chinese wholesalers by the ton.
FDA authorized a trial to commence immediate enrollment two years ago, the trial has still not yet started.
J11
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

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The In the Pipeline blog was trying to find the reason for TauRx going outside of the mainstream biotech structure for financing.

It seems obvious that the scientific community got locked into group think about amyloid. It was probably much easier (and more lucrative) for TauRx to sell their story to people who weren't already brainwashed.
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

Post by Ski »

I had missed this thread...until I read an article in LEF where Rick Rosner ( who is credited with having the world’s second-highest IQ) said he takes this in his longevity protocol. http://www.lef.org/Magazine/2015/4/Rick-Rosner/Page-01
I know on the longecity forum they discuss it at length.

Ive ordered some to see if there is any brain effect as some users describe. Will keep you posted.
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

Post by Tincup »

Ski,

What is your source of the MB that is high enough grade to consume?
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

Post by Ski »

George -
I poked around the forums and the consensus seemed that their was some concern of excess metals in some products but that this was so small...not much more than what was in drinking tap water. So seems like most people order this: http://www.amazon.com/gp/product/B00025646W/

I didnt want to mess with mixing as it comes premixed, so went with this: http://www.ebay.com/itm/161631205892 based on another users find.

You can find dosing and product info discussed here: http://www.longecity.org/forum/topic/51 ... -products/
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

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E3/E4
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Re: Methylene Blue Phase 2 Results Published Finally- Halts Progression of AD

Post by Julie G »

Fascinating interview with Rick Rosner. Thanks, Ski!
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