Re: Hormone Replacement Therapy E4 Women
Posted: Tue Jul 13, 2021 8:38 am
Thanks for sharing!SusanJ wrote:New study by Roberta Diaz Brinton's group.
Thanks for sharing!SusanJ wrote:New study by Roberta Diaz Brinton's group.
Thank you for posting that! n = 379,352 women!SusanJ wrote:New study by Roberta Diaz Brinton's group...
https://n.neurology.org/content/early/2 ... 0000012941All menopausal groups exhibited lower GMV in AD-vulnerable regions as compared to men, with peri-menopausal and post-menopausal groups also exhibiting lower GMV in temporal cortex as compared to the pre-menopausal group. Reproductive span, number of children and pregnancies, use of HT and HC were positively associated with GMV, chiefly in temporal cortex, frontal cortex, and precuneus, independent of age, APOE-4 status, and midlife health indicators. Although reproductive history indicators were not directly associated with cognitive measures, GMV in temporal regions was positively associated with memory and global cognition scores.
Thanks. That's quite an interesting. I wonder if # of children and other exposures to estrogen could cancel each other out to any degree. In other words, for women who don't have children, by choice or circumstance, can HC + HT sufficiently offset the benefit that pregnancies and having children can provide? I hate to think that women should feel pressure to have a family that includes their own children in order to decrease their chances of later cognitive decline. The second link to the summary provides some hope that subsequent research will delve into that more:SusanJ wrote:From Weill Cornell Medicine researchers, in collaboration with the University of Arizona:
https://n.neurology.org/content/early/2 ... 0000012941All menopausal groups exhibited lower GMV in AD-vulnerable regions as compared to men, with peri-menopausal and post-menopausal groups also exhibiting lower GMV in temporal cortex as compared to the pre-menopausal group. Reproductive span, number of children and pregnancies, use of HT and HC were positively associated with GMV, chiefly in temporal cortex, frontal cortex, and precuneus, independent of age, APOE-4 status, and midlife health indicators. Although reproductive history indicators were not directly associated with cognitive measures, GMV in temporal regions was positively associated with memory and global cognition scores.
GMV is gray matter volume. HT is hormonal therapy and HC is hormonal contraceptives.
Article behind a paywall.
Here's a summary of the research if you don't want to search for the paper.
"We're hoping now to get further into the details of these links between estrogen and GMV, for example by comparing the effects of surgical menopause and spontaneous menopause, and by focusing specifically on certain types of estrogen exposure, such as menopause hormone therapy," said study first author Eva Schelbaum, research assistant in Dr. Mosconi's laboratory. [Emphasis added]
Hello NS99 and a warm welcome to you!NS99 wrote: ↑Wed Dec 22, 2021 7:21 am Hi all, new to this site and just wondered if anyone can recommend any Drs in the UK who understand hormones and the link to dementia (and prescribe HRT). I've been desperately trying to find someone who understands early perimenopause (itself a risk factor for dementia), only to discover I also have a copy of APOE 4...
I've checked in the recommended practitioners list but there is nothing relevant.
Thanks in advance!
Hi NS99, this is from our Wiki on ApoE4 aware health providers:
SummaryThe researchers tested what happened when a potent form of estrogen, called estradiol, was given to mice in three groups: those with two copies of E3, those with two copies of E4, and those with one copy of E3 and one copy of E4. Estradiol was delivered directly into a part of the brain called the hippocampus that’s one of the first brain regions to deteriorate in Alzheimer’s.
They discovered that two copies of E4 inhibited estradiol’s ability to enhance memory for the location and identity of objects, and to improve neuron communication by promoting connectors called “dendritic spines.” In contrast, estradiol improved memory and increased the density of dendritic spines in the hippocampus of mice with one or two copies of E3.
Dendritic spines are knob-like structures that proliferate along dendrites, the “communication lines” on neurons. Neurons connect to each other at dendritic spines, so a loss of dendritic spines reduces communication in the brain. In an Alzheimer’s brain, spines in the hippocampus disappear first, making it an early indication of cognitive decline...
Estrogens influence cell function by binding to estrogen receptors – including receptors alpha and beta – inside cells. The alpha receptor, but not the beta receptor, is associated with the cancer-causing effects of estrogen therapy, so Frick’s team at Estrigenix has focused on creating highly selective compounds to target the beta receptor.
For E4/E4 animals that have shown no effects to estrogen treatment, the problem could lie with the alpha receptor, Frick said. The researchers have seen an elevated number of alpha receptors in E4/E4 animals.