Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

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laurie
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by laurie »

jozef wrote:
laurie wrote:
circular wrote:

Regarding filters and making Silicade, you have to use the Brita filter for making the Silicade. This step can not be eliminated as there are impurities in the ingredients which need to be removed. The Brita filter is unique as it filters out aluminum but does not filter out the OSA....
Hi ALL,
I have an idea and i need your opinion of it
If the OSA remove harming aluminum from body So i guess it will remove it from the silicade water (unless the amount of harming aluminum in the impurities is so much) so in that case we can use regular carbon filter to get rid of the other impurities and i think we will not need to add baking soda to water and we will only have to add little sodium bisulfate to reach the ph 7 of water .
So what do you think about this ?
My husband Dennis N Crouse developed this recipe. What you are proposing is UNSAFE. There is a reason for each step in this procedure and each step needs to be implemented. Here is information from the recipe.

"Why This Recipe Works
The goal of this recipe for orthosilicic acid (OSA) in drinking water is to use an easily measured solid silica powder and an acidic microprill that are commercially available online and shipped to anyone, not just chemical laboratories. Both of these chemicals are high purity (e.g. 99.5%).

· Solubilize sodium silicate: Boiling powdered sodium silicate for 30 seconds in an eighth of a cup of tap water keeps the pH high enough (e.g. pH = 13) to solubilize silicate434-436.

· Neutralize to form OSA and prevent polymerization: In order to form OSA and other silica species in equilibrium with OSA489 and to prevent OSA polymerization435-437, immediately dilute the basic (e.g. pH=13) OSA solution to a gallon with tap water and then immediately render the solution non-hazardous by acidifying the solution to pH 4 to 5 with the solid acid sodium bisulfate. A 1.29mM OSA solution is well below OSA’s saturation level in water (e.g. 2-3mM) but requires 7 days to fully stabilize rising from 108ppm immediately after preparation to 124ppm174. Polymerization of OSA has been observed at neutral pH only well above OSA’s 200ppm saturation level435-437.

· Remove Aluminum: For optimal aluminum removal acidify the OSA solution with sodium bisulfate to pH 4.0 to 5.0 and then filter through a Brita pitcher style filter (OB03)174. A significant portion (e.g. 98.5%) of the labile aluminum introduced in tap water is removed174,175. This Brita filter is a combined activated carbon and weak cation exchange resin that removes cations like aluminum but does not remove OSA174. If the tap water used for Silicade is between pH 6.5 to 8.5, as per EPA’s secondary drinking water standard, then after acidification, filtration, and bicarbonate addition Silicade will be pH 6.5.

· Optionally add Calcium and/or Magnesium: Have your tap water checked and if it is low in calcium and/or magnesium, add supplemental calcium and/or magnesium to Silicade. The Brita filter reduces calcium and magnesium in Quabbin tap water by one half175. Drinking water with calcium at levels of 80mg and magnesium at levels of 20 ppm has been found to be optimal for good health438. This may be due to calcium and magnesium competing with aluminum for absorption by the gut433. Calcium catalyzes the polymerization of OSA but only at pH greater than 818,19. Silicade + Ca is pH 6.6 and at this pH OSA in Silicade + Ca is primarily a non-polymeric monomer174,439. "
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by lgoring »

jozef wrote:]
Hi ALL,
I have an idea and i need your opinion of it
If the OSA remove harming aluminum from body So i guess it will remove it from the silicade water (unless the amount of harming aluminum in the impurities is so much) so in that case we can use regular carbon filter to get rid of the other impurities and i think we will not need to add baking soda to water and we will only have to add little sodium bisulfate to reach the ph 7 of water .
So what do you think about this ?
Hello jozef,

I do not know the answer to your question but I wanted to welcome you to the ApoE4 website! I hope someone on this thread will be able to answer you question. But while you wait, feel free to poke around the site!

If you are interested in learning the science behind the ApoE4 gene, checkout the Primer. It was posted by a physician that is currently one of the moderates for the site. If you haven't seen the Wiki, it has a collection of more information, strategies, and resources for the ApoE4 gene. Our newest edition to the Wiki page is the current ApoE4 Research opportunities. If you have any other questions, do not hesitate to press the quotes like you did in your last post and it will tag me.

See you around the forum,

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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by jozef »

laurie wrote:
My husband Dennis N Crouse developed this recipe. What you are proposing is UNSAFE. There is a reason for each step in this procedure and each step needs to be implemented. Here is information from the recipe.

Thank you for your reply,

I respect your opinion, but if the goal of publishing the formula is for the general benefit of the largest number of people who are afflicted with or at risk of Alzheimer's, then perhaps we should try to think of simpler steps as another option that is more widely applicable even it is not ideal , it is true that the formula is in its current form is ideal, but in my opinion it will benefit only a limited number of people who can apply it to the letter.
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by Tincup »

jozef wrote: in my opinion it will benefit only a limited number of people who can apply it to the letter.
I've been making ~3 gallons a week (as a 3 gallon batch) for my 4/4 wife and myself for 8 months. Not hard, does take a bit of time. I did invest in a digital microgram scale to measure the quantities of sodium silicate & sodium bisulfate.

Naturally high OSA silica water, such as Fiji, also works if you don't/can't make your own.
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by laurie »

jozef wrote:
laurie wrote:
My husband Dennis N Crouse developed this recipe. What you are proposing is UNSAFE. There is a reason for each step in this procedure and each step needs to be implemented. Here is information from the recipe.

Thank you for your reply,

I respect your opinion, but if the goal of publishing the formula is for the general benefit of the largest number of people who are afflicted with or at risk of Alzheimer's, then perhaps we should try to think of simpler steps as another option that is more widely applicable even it is not ideal , it is true that the formula is in its current form is ideal, but in my opinion it will benefit only a limited number of people who can apply it to the letter.
I appreciate you trying to make the Silicade available to "the largest number of people" however your proposals are UNSAFE. I disagree with you that the Silicade recipe will only benefit a limited number of people. The interest in this recipe has been more that we expected. Close to 100,000 people have viewed the video or read the recipe. I am sure all these people aren't making the recipe but this is a lot of people. As Tincup states in the next thread Silicade is easy to make.
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by Tincup »

laurie wrote: .
Laurie just posted this Aluminum FAQ to her FB group

Thought it would be good to post it here.

How much water should I drink?
3 to 4 cups a day. Spread the drinking throughout the day. If you do an activity that makes you sweat drink some silica water before the activity.

How long before I see improvement?
2 to 4 months.

Where do I buy the supplements, PQQ, CoQ10 etc?
Make sure there is only one active ingredient. I have seen a few companies add an ingredient. Look for GMP(good manufacturing practice). NSF international registers companies that have meet the GMP guidelines. Here are a few companies that meet GMP guidelines and have been in business for a while : Swansons (1969), Pipping Rock (1971), Jarrow (1977), Life Extensions (1980). There are other companies that meet this criteria.

Can I take a silica supplement?
No. The form of silica needed to remove aluminum from the body is OSA (orthosilicic acid). My husband Dennis N Crouse has tested many silica supplements such as horsetail, biosil, diatomaceous earth for OSA and none of these products contain enough OSA to remove aluminum. Mineral water is the only source of enough OSA.

Where can I find Silica Rich Water?
There are many bottled waters that contain enough silica in the form of OSA (orthosilicic acid) to remove aluminum from the body. Here is a link to a list. https://prevent-alzheimers-autism-strok ... evels.html
You can also make your own. Dennis N Crouse who is a chemist has developed a recipe called Silicade.
http://prevent-alzheimers-autism-stroke ... m/2017/09/
Here is information on reading the label of bottled water for the (OSA) orthosilicic acid levels. There are 3 units of measure used to report orthosilicic acid levels,
1. to convert silicon (Si) to OSA - multiply by 3.4
2. to convert silica SiO2 to OSA multiply by 1.6
3. orthosilicic acid or silicic acid Si(OH)4 doesn’t need to be converted. The units can be ppm or milligrams per litre, these are equivalent units of measure.
You need 48 ppm or more of OSA to remove aluminum.
Aluminum FAQ.pdf
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by CAngelS »

laurie wrote: Sat Oct 17, 2020 10:00 am
circular wrote:Laurie and others, ConsumerLab says in their boron review that citrate containing supplements increase the absorption of aluminum from medicines and foods. They claim if you don't have kidney issues and don't take aluminum containing medicine's, it's okay. I don't recall this coming up before but may have missed it. I suspect a lot of us take citrate containing supplements. Maybe if we're otherwise not ingesting any aluminum (maybe requires eating all organic everything?) it's okay. Dunno.
Once again you have found some important and interesting information. Thanks. Here is a write up my husband did on what he found. Yes we should be careful about taking supplements containing citrates with the exception of calcium citrate. More importantly we need to focus on identifying sources of aluminum in our daily lives and eliminating as many as we can.

Citrate’s Effect on Aluminum Absorption, Accumulation, and Elimination

Dennis N. Crouse, PhD 10/16/20

Citrate increases both absorption and elimination of aluminum: Calcium citrate 0.95 grams per day taken with 2.4gr/day of aluminum hydroxide increases urinary aluminum by as much as 11-fold as compared with a control group only given aluminum hydroxide. However, plasma aluminum levels were the same in the two groups. Aluminum accumulation was not measured1. Therefore, to prevent aluminum absorption do not mix citrate with aluminum containing drugs, such as antacids. There are aluminum free antacids.

Aluminum accumulation depends upon the ion paired with citrate: Over a 4-week period daily ferric citrate corresponding to 2 to 4 grams of citrate a day increased the accumulation of aluminum from food 2-fold in the brain and 20-fold in the bones2. Calcium taken daily at 1 gram of calcium as calcium citrate and 2 grams of calcium a day as tricalcium citrate for 24 months showed no change in urinary and plasma aluminum levels and no aluminum accumulation in bones3. Therefore, to prevent aluminum accumulation only take calcium citrate. Avoid other citrates not containing calcium.

Aluminum elimination depends upon the ion paired with aluminum: Intravenous administration of aluminum citrate compared with aluminum sulfate proved that aluminum excretion is enhanced with citrate but not when it is paired with sulfate4. Oral administration of citric acid in orange juice (approximately 17,000ppm5) laced with aluminum compared with the same mixture with 10ppm orthosilicic acid added, proved that orthosilicic acid at over 1,000 times less concentration than citric acid either increases aluminum elimination 10-fold or decreases absorption of aluminum 10-fold6. Based upon the work of Chris Exley it is now know that the former is true7. Therefore, to increase aluminum excretion and remove accumulated aluminum from the body, drink orthosilicic acid in silica rich water.

References
1. Coburn, J.W., et al.; Calcium citrate marked ly enhancers aluminum absorption from aluminum hydroxide; Am. J. Kidney Dis.; Jun.; 17(6):708-11 (1991)
2. Gupta, A.; Ferric citrate hydrate as a phosphate binder and risk of aluminum toxicity; Pharmaceuticals (Basel); Sep: 7(10):990-8 (2014)
3. Sakhaee, K., et al.; Calcium citrate without aluminum antacids does not cause aluminum retention in patients with functioning kidneys; Bone Miner; Jan.; 20(1):87-97 (1993)
4. Shirley, D.G., and Lote, C.J.; Renal handling of aluminum; Nephron. Physiol.; 101:99-103 (2005)
5. Penniston, M.D., et al.; Quantitative assessment of citric acid in lemon juice, lime juice, and commercially-available fruit juice products; J. Endourol.; Mar.; 22(3):567-70 (2008)
6. Edwardson, J.A., et al.; Effect of silicon on gastrointestinal absorption of aluminum; Lancet; 432:211-2 (1993)
7. Exley, C., et al.; Non-invasive therapy to reduce the body burden of aluminum in Alzheimer’s disease; J. Alzheimer’s Disease; 10:17-24 (2006)
I've donated blood a few times over the last several months (with the happy outcome of lowering my ferritin levels as well as giving to those in need), and I donated platelets once, as well. I had a fairly strong (but not disqualifying) response to the citrate they circulate into your blood when donating platelets and wondered if that's a problem??

If I understand their information correctly, the anticoagulant used in the platelet collection process is acid citrate dextrose (ACD).

https://www.redcrossblood.org/content/d ... _rwv01.pdf
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by laurie »

"I've donated blood a few times over the last several months (with the happy outcome of lowering my ferritin levels as well as giving to those in need), and I donated platelets once, as well. I had a fairly strong (but not disqualifying) response to the citrate they circulate into your blood when donating platelets and wondered if that's a problem??

If I understand their information correctly, the anticoagulant used in the platelet collection process is acid citrate dextrose (ACD)."

You should be concerned. This is a mixture of citric acid and dextrose and it will facilitate the absorption of aluminum. I asked Dennis Crouse my husband who is a chemist for this answer.
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

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laurie wrote: Sat Oct 17, 2020 10:00 am Citrate’s Effect on Aluminum Absorption, Accumulation, and Elimination
Therefore, to prevent aluminum accumulation only take calcium citrate. Avoid other citrates not containing calcium.
I take 31 g/day of potassium citrate (4g potassium) as I'm subject to kidney stones & the citrate is a preventative. I take a lot of it early in the day, about 4 hours prior to eating. After reading what it can to absorption, I will consume most of it away from other food. I also drink homemade Silcade daily. I will make sure I use it to mix with the K-citrate powder.

Looking at this paper: J Am Coll Nutr. 1996 Feb;15(1):102-6. doi: 10.1080/07315724.1996.10718572.
The lack of influence of long-term potassium citrate and calcium citrate treatment in total body aluminum burden in patients with functioning kidneys, K Sakhaee 1, L Ruml, P Padalino, S Haynes, C Y Pak Abstract

From the full text, "Although the bone biopsy remains the definitive "gold standard" for the diagnosis of aluminum-related bone disease, it is invasive, not readily available [23] and cannot exclude the possibility of non-skeletal aluminum burden. The use of the chelating agent deferoxamine may enable one to possibly est mate the total body store of aluminum noninvasively by measuring the serum and urinary aluminum after an intravenous infusion. Our current study corroborates our previous findings [7-9], showing no increase in the total body burden of aluminum after long-term citrate treatment (Fig. 1). After daily administration of citrate for as long as 2 to 8 years, there is no significant increase in either urinary or serum aluminum when the chelating agent deferoxamine is given. The median change of 17.1 ,...g1day in urinary aluminum in normals was not significantly different from the 18.7 ,...g1day change measured in the patient group (p = 0.0001). The findings suggest that both potassium and calcium citrate can be safely given for long periods without the fear of significant aluminum retention in patients with normal renal function."
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Re: Aluminum as a causal factor of Alzheimer's - Introduction of myself to the community

Post by CAngelS »

laurie wrote: Tue Jan 11, 2022 5:11 pm You should be concerned. This is a mixture of citric acid and dextrose and it will facilitate the absorption of aluminum. I asked Dennis Crouse my husband who is a chemist for this answer.
Tincup wrote: Tue Jan 11, 2022 6:19 pm Looking at this paper: J Am Coll Nutr. 1996 Feb;15(1):102-6. doi: 10.1080/07315724.1996.10718572.
The lack of influence of long-term potassium citrate and calcium citrate treatment in total body aluminum burden in patients with functioning kidneys, K Sakhaee 1, L Ruml, P Padalino, S Haynes, C Y Pak Abstract

From the full text, "Although the bone biopsy remains the definitive "gold standard" for the diagnosis of aluminum-related bone disease, it is invasive, not readily available [23] and cannot exclude the possibility of non-skeletal aluminum burden. The use of the chelating agent deferoxamine may enable one to possibly est mate the total body store of aluminum noninvasively by measuring the serum and urinary aluminum after an intravenous infusion. Our current study corroborates our previous findings [7-9], showing no increase in the total body burden of aluminum after long-term citrate treatment (Fig. 1). After daily administration of citrate for as long as 2 to 8 years, there is no significant increase in either urinary or serum aluminum when the chelating agent deferoxamine is given. The median change of 17.1 ,...g1day in urinary aluminum in normals was not significantly different from the 18.7 ,...g1day change measured in the patient group (p = 0.0001). The findings suggest that both potassium and calcium citrate can be safely given for long periods without the fear of significant aluminum retention in patients with normal renal function."
Thanks, Laurie & Tincup!

I would be interested in how long (&/or significant) the impact of the acid citrate dextrose might be on aluminum absorption(?) Any sense of that, Laurie?

And I'm interested in the paper you referenced also, Tincup. With so many contra-indicated issues to juggle at times, it sounds like you're taking wise steps to protect yourself.
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