Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

Conferences, webinars, and other gatherings; online and in person.
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JML
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

Post by JML »

anniew4 wrote: Mon Mar 28, 2022 7:21 pmWould it be possible to join in on the next call?
Looking forward to learning from this group!
Annie
Hi Annie--I will send you a private message (look for the envelope icon next to your name in the upper right corner). If you are willing to share your email, I will send you a calendar invitation for the next meeting (when we pick a date!). So glad to have you join us!
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

Post by Proverbs31_Woman »

Good morning,

I would like to join these calls. How do I register?
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

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Proverbs31_Woman wrote: Thu Apr 28, 2022 4:29 am Good morning,

I would like to join these calls. How do I register?
Good morning! I just wanted to let you know that JML, who moderates this virtual meet-up, checks this forum regularly and will send you a Private Message. You should get an email from her as well as a number 1 showing up on the envelope icon next to your user name in the upper right corner. The next meeting will probably be in the summer, so you'll have plenty of time to respond. Always nice to have someone join from Canada!
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

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Proverbs31_Woman wrote: Thu Apr 28, 2022 4:29 am Good morning,

I would like to join these calls. How do I register?
Hello--I sent you a private message with information on joining. As soon as we pick the next date to meet, I'll post it here. We look forward to meeting you!
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

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The next virtual Meet-up will be on Saturday June 4 at 3:00-4:30 pm CDT. I'll send out a calendar invitation to all who have shared their email addresses with me. Hope to see you all there!
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

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Just a reminder that the Virtual Meet-up will take place tomorrow Saturday June 4 at 3:00-4:30 pm CDT. The Zoom link has been sent out in a calendar invitation--let me know if you did not receive it and would like to attend.
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

Post by mike »

Can someone tell me where the date of emergence of ApoE3 at 220,000 years ago came from? When I follow the references, neither seems to have any evidence for that date? At one point, I found a paper that used a model to come up with something like that, but I can no longer find it - besides, it stated that their numbers could be way off since they were assuming no evolutionary pressure, which seems unlikely...
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

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mike wrote: Mon Jun 06, 2022 12:55 pm Can someone tell me where the date of emergence of ApoE3 at 220,000 years ago came from? When I follow the references, neither seems to have any evidence for that date? At one point, I found a paper that used a model to come up with something like that, but I can no longer find it - besides, it stated that their numbers could be way off since they were assuming no evolutionary pressure, which seems unlikely...
Hi Mike, I know I have read that date of emergence of ApoE3 many times. I just found this in Dr Bredesen’s first book as a footnote to a paragraph on emergence of both ApoE3 and ApoE2.
Scientists can date the appearance of mutations by counting how much they differ from what came before-in this case ApoE3 and ApoE2 vs. ApoE4- and knowing roughly, how many thousands of years it takes for that amount of change to occur.
(pg 100, The End of Alzheimer’s )
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

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mike wrote: Mon Jun 06, 2022 12:55 pm Can someone tell me where the date of emergence of ApoE3 at 220,000 years ago came from? When I follow the references, neither seems to have any evidence for that date? At one point, I found a paper that used a model to come up with something like that, but I can no longer find it - besides, it stated that their numbers could be way off since they were assuming no evolutionary pressure, which seems unlikely...
Sounds like I missed an interesting discussion on Saturday.

Is this the paper you were thinking of: Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human
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Re: Virtual Meet-up (formerly called Book Club: The End of Alzheimer's Program)

Post by mike »

floramaria wrote: Mon Jun 06, 2022 2:05 pm Hi Mike, I know I have read that date of emergence of ApoE3 many times. I just found this in Dr Bredesen’s first book as a footnote to a paragraph on emergence of both ApoE3 and ApoE2.
Scientists can date the appearance of mutations by counting how much they differ from what came before-in this case ApoE3 and ApoE2 vs. ApoE4- and knowing roughly, how many thousands of years it takes for that amount of change to occur.
(pg 100, The End of Alzheimer’s )
Thanks for responding floramaria, A few years ago, they were saying that E3 came out much more recently (40,000 years ago?), and I'm trying to find where the new numbers come from. Scientists doing this kind of work are making a number of assumptions. The article I saw had the current numbers, but they made it clear that it could be off by a huge amount if their assumption that E3 had no evolutionary advantage was wrong. I find it hard to believe that it had no advantage for people eating fast carbs. Also, these are just mathematical models - I haven't seen any fossil evidence that ApoE3 existed that long ago.
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