ApoE4.Info

TheresaB wrote: ↑Mon Jun 06, 2022 3:34 pm Is this the paper you were thinking of: Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human

JML wrote: ↑Tue Jun 07, 2022 1:54 pm Notes and Resources from our Saturday Meet-up:
Watch this space for the next scheduled Virtual Meet-up (probably in August).

As noted above, the net sequence divergence between human and chimp APOE genes was estimated as 64.7; the average pairwise sequence difference among human haplotypes in the same genomic region was 2.93. If a constant molecular clock is assumed and the humans-chimpanzee time of divergence is taken as 5 million years BP, the time required to generate the observed variation would be ∼226,000 years.

A key assumption underlying these analyses is that the variation is selectively neutral. If this assumption is met, then these analyses suggest that the divergence between η4 and the η2 and η3 clades (dated by the mutation at site 3937) began ∼200,000 years ago and that most of the subsequent intraallelic divergence has occurred only comparatively recently in human history, within the past 60,000 years. If, instead, selection has acted to increase the relative frequency of the mutation at site 3937 (as discussed below), then the inferred ages may overestimate the antiquity of the η2-η3-η4 polymorphism, because sites in the sample would then be at a higher relative frequency than expected, given the influence of random genetic drift alone. In either case, the recent origin of the APOE protein polymorphism suggested by these age estimates is not consistent with the long-standing maintenance of the η2, η3, and η4 alleles in human populations as a balanced polymorphism.

JML wrote: ↑Sun Nov 21, 2021 7:52 pmInfrared Sauna Blanket:
Here is the US website for MiHIGH https://www.mihigh.com

circular wrote: ↑Tue Jul 12, 2022 2:32 pm

JML wrote: ↑Sun Nov 21, 2021 7:52 pmInfrared Sauna Blanket:
Here is the US website for MiHIGH https://www.mihigh.com

I was hoping this might be on sale as part of Amazon Prime, but no dice. Is it possible that some of the cheaper sauna blankets are just as good? Does this only cost more because maybe it was the first one out? I realize no EMF probably carries a premiu. Has anyone looked into alternative makers? The blanket is the best possible way for me to get the infrared sauna benefits for a number of reasons.

I also don't have time to delve into the tradeoffs between infrared and near infrared saunas, so any feedback about that would be helpful too.

JML wrote: ↑Sun Jul 17, 2022 1:43 pm

circular wrote: ↑Tue Jul 12, 2022 2:32 pm

JML wrote: ↑Sun Nov 21, 2021 7:52 pmInfrared Sauna Blanket:
Here is the US website for MiHIGH https://www.mihigh.com

I was hoping this might be on sale as part of Amazon Prime, but no dice. Is it possible that some of the cheaper sauna blankets are just as good? Does this only cost more because maybe it was the first one out? I realize no EMF probably carries a premiu. Has anyone looked into alternative makers? The blanket is the best possible way for me to get the infrared sauna benefits for a number of reasons.

I also don't have time to delve into the tradeoffs between infrared and near infrared saunas, so any feedback about that would be helpful too.

The only other sauna blanket that I have heard is low EMF is the Higher Dose, but it looks like it is even more expensive. I'm sorry that I don't know more about any of the cheaper ones. I think you do have to pay more to get lower EMF.

circular wrote: ↑Tue Jul 12, 2022 2:32 pm I also don't have time to delve into the tradeoffs between infrared and near infrared saunas, so any feedback about that would be helpful too.