I am not an expert and don’t have Apoe4, but I have the same prodrome pattern, (and my father has NAFLD).Gail wrote: ↑Thu Jun 09, 2022 3:26 pmThanks for your comments SusanJ! I think that's wise advice to look into other causes for the my low phosphatidylcholine. Thanks for the link to the wiki on Homocysteine. Will do. These systems are so complex - but I will work on my methylation and see if that helps.SusanJ wrote: ↑Wed Jun 08, 2022 9:41 pmuu
With MTHFR variants and given your higher homocysteine level, I'm guessing that your body might just be using your choline intake (via food) to help with methylation (due to lack of B vitamins), which means it's not available for making phosphatidylcholine. You're on the right track in thinking about this, and might just need to fiddle with your B vitamin intake, perhaps add some choline (or choline containing foods), and/or take phosphatidylcholine as a supplement (fairly inexpensive).
Honestly, I'd start there, to optimize your methylation pathways and see where it leads you. These actions will likely bring your homocysteine down, too. If it doesn't, then add the TMG.
I am taking Prodrome Glia for white matter inflammation issues derived from Lyme Disease. I haven’t found a single thread discussing Dayans work other than this. So please keep the discussion going.
I suspect my issue is that I have several genetic variants that might be contributing:
rs7946 T/T:
PEMT pathway is responsible for the body’s production of phosphatidylcholine, which is part of the phospholipid bilayer making up the membranes surrounding our cells. The PEMT enzyme is key in the body’s ability to create choline. Genetic variants that decrease the function of the enzyme cause greater reliance on choline from dietary sources.
rs10791957:
> - A/C: reduced turnover of methionine to phosphatidylcholine
Plus:
rs18J01133: >- A/G: one copy of **MTHFR C677T** allele, enzyme function decreased by 40%
Haven’t tested my father on prodrome (yet), but for me, I tested on the 2nd percentile for Total PhosphatidylCholine at age 32 and with a healthy diet. After 3 months of taking 10g a day of Sunflower lecithin I only went up of the 12th percentile. So I am taking now PC capsules in addition. Will test again soon and share my results.