Top articles / recent research

[TheresaB]

In addition to this website, we (ApoE4.info) have a Facebook page https://www.facebook.com/apoe4.info where current research/articles of interest are posted. Here are the top 10 Facebook papers/articles that generated the most interest during the fourth quarter (Oct – Dec) of 2022.

1 Posted Oct 15, 2022
4 Benefits Of Regular Sauna Use, From Brain Health To Longevity
https://www.mindbodygreen.com/articles/ ... HSyvDjOo3k
Both neurologist Dale Bredesen, M.D., author of "The End of Alzheimer's", and energy specialist Ari Whitten, author of "Eat for Energy", sing the praises of the mighty sauna.

2. Posted Nov 23, 2022
Time-restricted eating may benefit Alzheimer's
https://www.news-medical.net/news/20221 ... dQAe01UwPw
In a recent study published in the Experimental Gerontology journal, researchers in the United States assessed the impact of time-restricted eating (TRE) on Alzheimer's disease (AD), cognitive decline, and sleep.

3. Posted Dec 17, 2022
Factors Linked to Optimal Aging Uncovered
https://neurosciencenews.com/optimal-ag ... 3yOWQD_Qwk
ApoE4s have more to be concerned with than just Alzheimer’s. While our gene seems to serve us well when young, it doesn't do us any favors when we age. But there are things we can do to help ourselves age well. What are the keys to “successful” or optimal aging? A new study followed more than 7000 middle aged and older Canadians for approximately three years to identify the factors linked to well-being as we age.

4. Posted Oct 24, 2022
Omega-3 fatty acids
https://www.foundmyfitness.com/topics/o ... p7jhvj2dNk
We’ve emphasized the importance of Omega-3 intake before, now here’s more to add to the pile. ApoE4s tend to be longevity challenged and predisposed to cardiovascular disease, but Omega-3s can help with that:
• Having low omega-3 levels ranks among the top six causes of preventable death – right up there with smoking, high blood pressure, and obesity.
• Having high omega-3 levels may reduce a person's risk of cardiovascular disease by a whopping 25 percent.
• Taking omega-3s is associated with an additional five years of lifespan, on par with not smoking.

5. Posted Dec 20, 2022
Walnuts the New Brain Food for Stress
https://neurosciencenews.com/walnuts-st ... noWA3GbSSU
Walnut consumption was associated with increased improvements in self-reported mental health and stress. It was also linked to improved sleep quality and metabolic biomarkers. Walnuts contain omega-3 fatty acids, melatonin, and other vitamins and nutrients associated with mental and gut health.

6. Posted: Oct 19, 2022
Study Shows What Causes our Bodies to Age Faster
https://medium.com/illumination/study-s ... 8bb5c355cb
The women who experienced healthy longevity, compared to the ones who lived to 90 but didn’t have healthy longevity or just didn’t make it to 90, were more likely to have these characteristics:
• They were white
• Had no major chronic health conditions
• Graduated from college
• Had no history of smoking
• Walked 2 to 3 times a week or 4 to 6 times a week
• Had a normal BMI or were overweight
• Had more than 1 but fewer than 7 alcoholic drinks a week
• Had a higher average physical functioning score

7. Posted Dec 14, 2022
Subcutaneous fat emerges as a protector of females' brains
https://medicalxpress.com/news/2022-12- ... 7GzQDIQxlA
Females' propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause, scientists report.

8. Posted Dec 31, 2022
New Biomarker Test Can Detect Alzheimer’s Neurodegeneration in Blood
https://neurosciencenews.com/bd-tau-blo ... Uxf9g04R5k
A group of neuroscientists led by a University of Pittsburgh School of Medicine researcher developed a test to detect a novel marker of Alzheimer’s disease neurodegeneration in a blood sample.
A study on their results was recently published in “Brain”.

9. Posted Nov 26, 2022
A hibiscus compound may help remove toxic plaque build-up in Alzheimer's
https://www.medicalnewstoday.com/articl ... PTy23DBrpM
• Accumulation of toxic aggregates of the beta-amyloid proteins in certain brain regions is often linked to the decline in cognitive function characteristic of Alzheimer’s disease.
• Studies suggest that impaired clearance or removal of beta-amyloid may contribute to the accumulation of beta-amyloid in Alzheimer’s disease.
• A recent study shows that gossypetin, a flavonoid present in the flower of a hibiscus species, facilitated the clearance of beta-amyloid in the brain of an Alzheimer’s mouse model.
• Treatment with gossypetin also attenuated deficits in memory and learning in the mouse model, highlighting the therapeutic potential of this compound in Alzheimer’s disease.

10. Posted: Nov 29, 2022
4 Surprising Things That Can Impact Dementia, From A Psychiatrist
https://www.mindbodygreen.com/articles/ ... DzJZFq13bI
With cognitive decline, it's important to focus on early intervention and doing what you can to prevent the onset—but that's not to say you can't do anything about it once symptoms arise. In the podcast contained in this article, functional medicine psychiatrist Kat Toups, M.D shares how she healed her own serious autoimmune disease and cognitive impairment. "Gradually, there came a day that my brain came back online," she recounts. "It was really exciting when I realized I could hold the seven digits of a phone number in my head and dial the number again.”

[circular]

7. Posted Dec 14, 2022
Subcutaneous fat emerges as a protector of females' brains
https://medicalxpress.com/news/2022-12- ... 7GzQDIQxlA
Females' propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause, scientists report.

This reminds me of a recent episode of NOVA on PBS: The Truth About Fat. It can be viewed online. One takeaway … Sumo wrestlers don't have the chronic diseases that are associated with obesity despite their weight. The reason is their fat is subcutaneous, and their high level of exercise helps keeps the fat stores from becoming visceral.