40 hz gamma light and sound therapy

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FitFoodie
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40 hz gamma light and sound therapy

Post by FitFoodie »

I'm curious if anyone has tried 40hz light and sound therapy, on themselves or a loved one.

Here's the background. Gamma brain waves generated by this light and sound stimulation trigger the cleanup of brain detritus and improve memory.
https://www.pnas.org/content/117/31/18142

Here's info on the current clinical trials. One should have ended last fall.
https://www.cognitotx.com/participate/

Here's what I've been plugging into my ears for a few days. 40 hz sound
https://youtu.be/UVne_84qZkA

And this is the light bulb I bought. I think the price went up in the past few weeks. I paid less.
https://gammalighttherapy.com/collectio ... light-bulb

I don't have the patience for 60 minutes every day, and I do feel like a weirdo holing up in my bedroom for even 30 minutes of this. But it seems very promising (in mice ;) and probably no downside.

I'm curious if anyone else has tried this.
J11
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Re: 40 hz gamma light and sound therapy

Post by J11 »

Yes, I have bought the gamma light bulb recently as well.
(Just bought some 7,8 dihyroxyflavone (also thinking about the metabolic brain deficits in AD so cyclocreatine, possibly the antidote for methylglyoxal could go on the shopping list as well). Once we have an anti-amyloid on the market then a whole landscape of amplifying treatments could emerge.)

I also have a light and sound machine of a certain vintage that I have dusted off.
The problem is that this machine only gets up to 30 Hz and not 40 Hz.
To move to higher frequencies I would need to buy a more expensive machine.
Also have brain wave entrainment software.

The recently reported phase 2 result for Cognito in AD was impressive: 85% slowing of progression.
Phase 3 on its way.
https://www.businesswire.com/news/home/ ... -ADPD-2021

Anyone have a citation that gamma frequency entrainment lowers amyloid in humans?


See viewtopic.php?f=16&t=7579
FitFoodie
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Re: 40 hz gamma light and sound therapy

Post by FitFoodie »

J11 wrote:Yes, I have bought the gamma light bulb recently as well.
Thank you for replying with the research results and the link to the other thread.

I had tried searching the forum for light therapy and 40 hz but I must have used the wrong or too many keywords :)

It's interesting stuff and promising.
NewRon
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Re: 40 hz gamma light and sound therapy

Post by NewRon »

https://play.google.com/store/apps/deta ... n_US&gl=US

Would this suffice, when on Productivity setting (40Hz)? Doesn't work with the the Dark Side though, only Android...
Apo E4/E4, Male, Age 60
FitFoodie
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Re: 40 hz gamma light and sound therapy

Post by FitFoodie »

NewRon wrote:https://play.google.com/store/apps/deta ... n_US&gl=US

Would this suffice, when on Productivity setting (40Hz)? Doesn't work with the the Dark Side though, only Android...
I think the audio is probably good, but I've read that phones, tablets, laptops all have different ways of interfacing with video, making 40hz light flickering apps inaccurate. I'm not particularly knowledgeable on this though, just quoting :)
NewRon
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Re: 40 hz gamma light and sound therapy

Post by NewRon »

Thanks, that sounds like it could be a problem. Easier to buy a bulb!
Apo E4/E4, Male, Age 60
J11
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Re: 40 hz gamma light and sound therapy

Post by J11 »

Very exciting developments everyone!

I started using the gamma light today!
Very impressed.

I had it on for about half an hour and then I noticed a fairly powerful calming effect.
Lots of times with these mind improvement type technologies it is very unclear whether there is an treatment effect, though with the gamma light the benefit was almost immediate.

I'll try and find some cognitive test and report back some results (possibly use the PEBL software).

Another extremely exciting development was the arrival of my full genome sequence! Yeah!
This is truly truly startling. Only ~$299 and I have 30x coverage.
They offer about 250 polygenic scores, so there is value right out of the box.
Problem is that the scores that they are using are somewhat dated.
The current best AD polygenic scores has about 100 loci; the one reported with the genome is small possibly only ~20.

What was a surprise was the high risk that was reported for other neurodegenerative illnesses.
My Parkinson's risk was reported in the top 90th percentile. Having a mixed style of dementing illness could make
any possible future treatment much more complex. What Alzheimer's were cured though these other risks remained?

For others on forum it appears full genome sequencing has arrived though it might still be somewhat too early for those who
want everything to be sorted out ahead of time. One problem is that the vcf file with genetic variants is not completely annotated.
It would be much more convenient if such annotation were provided.
Family Tree Guy
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Re: 40 hz gamma light and sound therapy

Post by Family Tree Guy »

I have used 40Hz sounds and a 40 Hz light. However, since I have no way to ensure that they are actually synced, I have not really used them too much at the same time. I try to do 40Hz sounds for 1 hour every day while doing something else (reading, working on the computer, cleaning up the kitchen, whatever). I notice that it leads to very vivid and intense dreams. this makes sense because 40Hz is associated with REM sleep when we dream.
J11
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Re: 40 hz gamma light and sound therapy

Post by J11 »

Family Tree Guy, this is a very good point. Apparently differently modalities have different effects on the brain. I am starting out with single mode light flashing, though I might want to move to a more multi-modal approach in time. Add in sound, perhaps add in touch/vibration. There is likely a great deal of unexplored territory still left uncharted. It would be truly brilliant if one might be able to specifically focus the anti-amyloid effect on specific brain regions for example the frontal motor/sensory cortex. Maintaining ambulation is so critically important in AD. Preserving this function alone would be such an enormous benefit for dementia caregivers.
Family Tree Guy
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Re: 40 hz gamma light and sound therapy

Post by Family Tree Guy »

J11 wrote:Family Tree Guy, this is a very good point. Apparently differently modalities have different effects on the brain. I am starting out with single mode light flashing, though I might want to move to a more multi-modal approach in time. Add in sound, perhaps add in touch/vibration. There is likely a great deal of unexplored territory still left uncharted. It would be truly brilliant if one might be able to specifically focus the anti-amyloid effect on specific brain regions for example the frontal motor/sensory cortex. Maintaining ambulation is so critically important in AD. Preserving this function alone would be such an enormous benefit for dementia caregivers.
You could also check out these guys:
https://www.vielight.com/

they sell an intra-nasal 40Hz device (yes, up your nose). I would totally try it except for the price is pretty high.
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