A number of us have had our first metabolomics tests and have incorporated the supplements into our diets. Currently we are building a portal to gather additional biometric information and share our anonymized results publicly. We have named the project:Huge thanks to MarcR and efcole (Emily Cole, PhD, academic researcher) for continuing to work behind the scenes with Prodrome Sciences to create our longitudinal open-access dataset in which we plan to share our anthropometrics, multiple biomarkers including metabolomics, with periodic cognitive testing along with a description of our diets and lifestyle strategies. This framework will provide an opportunity for participants to conduct self-directed or “action” research (where patients and researchers authentically work together) that will not only inform themselves about how specific strategies affect their health and cognition, but also our community, and the broader scientific community. The metabolomic portion will provide an opportunity for us all to see how specific strategies are affecting us at a cellular level.
Dataset for the
That's MOD4 for short. Despite the 4, anyone is welcome to share results. The tests are not ApoE4-specific.
Our collaboration with Prodrome has several important features that support the project:
1. MOD4 participants receive test results directly via email in two formats. The first is the standard color-coded PDF result document that Prodrome delivers to all customers and that puts the numeric results in context. Is a given result optimal, sub-optimal, cautionary, or poor? If not optimal, is it high or low?
The second is a CSV file that is suitable for direct database import. Crucially, this means that you can forward the CSV file to email@example.com, and we can anonymize and import it automatically. There's no need for anyone to retype the results.
If you've previously had a ProdromeScan and would like to include that in the MOD4 project, simply write “For APOE 4 Research Project" on the top of the Test Requisition Form (1 page of the paperwork in the kit) at the time of your next blood test kit submittal to Prodrome. They will send your current and past results to you in a CSV file that you can pass along to us at firstname.lastname@example.org
2. Normally the ProdromeScan test is only offered through healthcare professionals. Prodrome has waived this requirement for our community.
3. Prodrome is offering discounts on tests and supplements for MOD4 participants. You can begin participating in the project by ordering blood tests here and blood test/supplement bundles here. There is no formal sign-up for members wishing to participate in MOD4. Please forward the CSV file(s) of your blood test(s) that you receive from Prodrome to the MOD4 project email, email@example.com. (The CSV file is best suited for direct database import.)
4. Anyone in our community is welcome to purchase blood tests and supplements from the Prodrome Store for a 25% discount with code APOE4GROUP25 at checkout.
To summarize, we have a bit of data, and we are working to incorporate it into a portal so we all can view the anonymized results. We would love to have more data, and we know that some of you have been eager to begin, hence our sharing this opportunity. For those who want to learn more about Dr. Goodenowe's work, we recommend the two podcasts here and the links under the Resources headings of the individual podcast pages.