statin and sartan drugs in ApoE4+ patients

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Quantifier
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statin and sartan drugs in ApoE4+ patients

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There have been several recent papers about how statins prevented mental decline, however none of those I saw stratified patients by ApoE status. I just found one from June 2020 that did that: Telmisartan and Rosuvastatin Synergistically Ameliorate Dementia and Cognitive Impairment in Older Hypertensive Patients With Apolipoprotein E Genotype. It was a placebo-controlled trial where participants (hypertensive people over 60 with no cognitive impairment) were randomized to receive either, both, or neither of the anti-hypertension drug telmisartan (dosage 40 mg/day, increased to 80 mg/day if needed) or the hydrophilic statin drug rosuvastatin (10 md/day) and followed up for 7 years. The participants were also genotyped for their ApoE status.

While all participant populations declined mentally *on average* over the course of the follow-up, receiving either drug reduced the rate of decline, and receiving both together reduced it even more. And this was true also for participants who were ApoE4 positive!
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