Age, Alzheimer’s related brain decline linked to little-studied enzyme

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Greyhound
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Age, Alzheimer’s related brain decline linked to little-studied enzyme

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floramaria
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Re: Age, Alzheimer’s related brain decline linked to little-studied enzyme

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This is an interesting discovery. I'll pull a few quotes from the article to make it easy to find HDAC9 with our Search
function.
A little-studied enzyme has been found in high levels in healthy neurons, levels that scientists say decline with age and more dramatically with Alzheimer’s, making adjusting the enzyme’s level a potential treatment for both.
The enzyme is called HDAC9...
The new grant is enabling them to look more closely at whether loss of HDAC9 in the hippocampus and prefrontal cortex mediates both age-related cognitive decline and the typically more dramatic cognitive decline and physical changes to the brain that occur in Alzheimer’s. That includes looking downstream of HDAC9 to better understand how it is regulating synaptic plasticity.
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