New Alzheimer’s biomarker may facilitate rapid diagnosis

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Greyhound
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New Alzheimer’s biomarker may facilitate rapid diagnosis

Post by Greyhound »

My comment about this is it will likely take a lot of time before it is used even as they say in the article that these markers are available with standard tests. I will copy the article and sometimes my source references another release of the article.
"Brain Chemistry Labs
Banack, Sandra Amino Acid Analyzer 2002_cropped.jpg

image: Dr. Sandra Banack Analyzing Alzheimer’s Blood Samples at the Brain Chemistry Labs in Jackson Hole. view more

Credit: © 2022 Paul Alan Cox

Although symptoms of advanced Alzheimer’s disease are well known, diagnosis of Alzheimer’s disease in its earliest stages requires careful cognitive testing by neurologists.

Discovery of a unique ratio of metabolites from blood samples of early-stage Alzheimer’s patients promises to speed diagnosis, allowing earlier treatments to be initiated.

“We were delighted to discover that the ratio of two molecules, 2-aminoethyl dihydrogen phosphate and taurine, allows us to reliably discriminate samples of early-stage Alzheimer’s patients from controls,” said Dr. Sandra Banack, lead author of the report in PLOS ONE and Senior Scientist at the Brain Chemistry Labs in Jackson Hole.

The blood samples were drawn from patients enrolled in an FDA-approved Phase II trial at Dartmouth Hitchcock Medical Center in New Hampshire and then shipped to the Brain Chemistry Labs for analysis.

Current attempts to diagnose Alzheimer’s disease from blood samples depend on the presence of amyloid fragments, the molecules that cause brain tangles and plaques. “At the Brain Chemistry Labs, we consider amyloid plaques to be a consequence rather than the cause of Alzheimer’s disease,” Dr. Paul Alan Cox, Executive Director of the Brain Chemistry Labs explains. “What is exciting about this new discovery is that it does not depend on amyloid and the assay can be performed on analytical equipment that is already present in most large hospitals.”

Their report, written with Alzheimer’s expert Dr. Aleksandra Stark, “A Possible Blood Plasma Biomarker for Early-stage Alzheimer’s Disease” is being published this week in PLOS ONE. "

https://www.eurekalert.org/news-releases/949897
Jay Ess
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Re: New Alzheimer’s biomarker may facilitate rapid diagnosis

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As the abstract doesn't tell us what 2-aminoethyl dihydrogen phosphate actually does, it was interesting to read the discussion section in the paper. 2-aminoethyl dihydrogen phosphate is a precursor to phosphatidylethanolamine and phosphatidylcholine. AD patients have lower levels in the brain, but much higher levels in the blood as this paper found.
NF52
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Re: New Alzheimer’s biomarker may facilitate rapid diagnosis

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Greyhound wrote: Thu Apr 21, 2022 7:54 pm ...Although symptoms of advanced Alzheimer’s disease are well known, diagnosis of Alzheimer’s disease in its earliest stages requires careful cognitive testing by neurologists.

Discovery of a unique ratio of metabolites from blood samples of early-stage Alzheimer’s patients promises to speed diagnosis, allowing earlier treatments to be initiated.

“We were delighted to discover that the ratio of two molecules, 2-aminoethyl dihydrogen phosphate and taurine, allows us to reliably discriminate samples of early-stage Alzheimer’s patients from controls,” said Dr. Sandra Banack, lead author of the report in PLOS ONE and Senior Scientist at the Brain Chemistry Labs in Jackson Hole.
..
Their report, written with Alzheimer’s expert Dr. Aleksandra Stark, “A Possible Blood Plasma Biomarker for Early-stage Alzheimer’s Disease” is being published this week in PLOS ONE. "

https://www.eurekalert.org/news-releases/949897
Jay Ess wrote: Sat Apr 23, 2022 6:50 am As the abstract doesn't tell us what 2-aminoethyl dihydrogen phosphate actually does, it was interesting to read the discussion section in the paper. 2-aminoethyl dihydrogen phosphate is a precursor to phosphatidylethanolamine and phosphatidylcholine. AD patients have lower levels in the brain, but much higher levels in the blood as this paper found.
Welcome to the forum, Jay Ess!

Your knowledge of nine-syllable terms suggests you have lots to contribute to this forum, maybe especially in the role of lipids and ApoE4. As a Support Team member, I wanted to share that our vintage software notifies people of replies to their post when the new poster starts from the original post, clicks on the quote icon in the upper right hand corner (as I did with your post) and then starts their reply.

You and Greyhound speak the same language--hope you share more gems and explanations with the rest of us!
4/4 and still an optimist!
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AnnaM
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Re: New Alzheimer’s biomarker may facilitate rapid diagnosis

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Jay Ess wrote: Sat Apr 23, 2022 6:50 am As the abstract doesn't tell us what 2-aminoethyl dihydrogen phosphate actually does, it was interesting to read the discussion section in the paper. 2-aminoethyl dihydrogen phosphate is a precursor to phosphatidylethanolamine and phosphatidylcholine. AD patients have lower levels in the brain, but much higher levels in the blood as this paper found.
Welcome Jay Ess! I am an intern here and appreciate your explanation of what this research may mean. Please do post as often as you can, as many here are keen on learning all they can about the current research.
You may have already looked around the site, but my job as an intern is to introduce you to the places in the guide that many find helpful.
The Primer is written by a medical doctor who is a 4/4 and is very helpful for the science behind the lifestyle. The How-To Guide answers questions about the website navigation. To learn about some of the members here, there is a section called Our Stories that familiarizes the reader with others' life-situations.
Thank you again for posting!
Best,
AnnaM
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Jay Ess
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Re: New Alzheimer’s biomarker may facilitate rapid diagnosis

Post by Jay Ess »

Thanks for the welcome. You have a lot of good content in these forums.
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