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New research on NR and Alzheimer's

Posted: Sat Jul 16, 2022 4:13 pm
by circular
Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease
Thus, although NR and caffeine can partially restore diminished NAD availability, increasing NAD alone may not be sufficient to boost or restore energy metabolism in brain aging or alter aberrant energy management in LOAD. Nicotinamide riboside might still be of value in combination with other agents in preventive or therapeutic intervention strategies to address the aging process or age-associated dementia.
Considering how complex AD pathophysiology is and that the trial studied NR in LOAD patients, this isn't surprising and doesn't really move us forward very much when it comes to prevention. I post it in case anyone is interested in taking a deeper dive.