Novel treatment approach to Alzheimer's disease uses vitamin B1 derivative

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Greyhound
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Novel treatment approach to Alzheimer's disease uses vitamin B1 derivative

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University of California - San Diego

With a $45 million grant from the National Institutes of Health and National Institute on Aging, the Alzheimer’s Disease Cooperative Study (ADCS) at University of California San Diego, in collaboration with Burke Neurological Institute (BNI) and Columbia University Irving Medical Center, will launch a nationwide clinical trial to further investigate the therapeutic potential of benfotiamine, a synthetic version of thiamine (B1), as a metabolic treatment approach to Alzheimer’s disease.

The trial advances the ADCS mission to develop and test therapies to benefit those at risk or experiencing the symptoms of Alzheimer’s disease (AD). ADCS will coordinate the multi-center trial to evaluate whether high doses of benfotiamine benefit people with mild AD or mild cognitive impairment due to AD (MCI).

The trial addresses tissue deficiency of thiamine-regulated metabolic pathways linked to AD. Previous work by co-principal investigator Gary E. Gibson, PhD, professor of neuroscience at Brain and Mind Research Institute, part of Weill Cornell Medicine, has found that a reduction in glucose metabolism is linked to this deficiency in thiamine-dependent processes.

Using multiple experimental models, Gibson and others have shown that increasing thiamine to very high levels using benfotiamine supplementation appeared to be protective against Alzheimer’s-like symptoms. For the study, ADCS will enroll approximately 400 patients at up to 50 U.S.-based clinical trial sites, beginning in early 2023.

“We are excited to receive this funding, which will enable expanded testing of benfotiamine through to its clinical proof of concept, including adaptively testing for the optimal dose and treatment response across clinical and biomarker measures,” said Howard Feldman, MD, dean of Alzheimer’s Disease Research and professor of neurosciences at UC San Diego School of Medicine.

The benfotiamine study will monitor participants over 18 months, using several measures, including cognitive tests and blood markers that signal AD and MCI status and progression.

"At the Burke Neurological Institute, we have been studying the effects of thiamine on neurodegenerative diseases for more than 40 years,” said Gibson. “This important grant will allow us to test the treatment with hundreds of Alzheimer's disease patients across the U.S. We are eager to begin this critical new stage of the research.

“I am particularly excited about this trial because it will determine how relevant these decades of research are to the treatment of Alzheimer’s disease.”

The trial highlights ADCS’ efforts to develop new interventional approaches. In collaboration with the University of Southern California, ADCS was the recent recipient of a $50 million gift from the Epstein Family Foundation to support two programs: one investigating the use of gene therapy to treat AD and the other a “powder for pennies” (P4P) program designed to expedite the testing of existing or repurposed drugs and natural products for its treatment.

Benfotiamine is a good example of the P4P approach. If found to be beneficial, the treatment would be widely available and affordable.

Educational and lifestyle interventions are other approaches being developed at ADCS. A study called HALT-AD, a pilot for the Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia, is a bilingual, bicultural program that recruits community members to join education programs and discussion groups, enabling them to learn more about dementia and to practice preventive measures.

The recently completed EXERT study, coordinated nationwide by ADCS, was a Phase III clinical trial to test whether physical exercise can slow the progression of mild memory loss and/or MCI in adults between the ages of 65 and 89. Results of the study will be presented at the Alzheimer’s Association International Conference in San Diego in late-July.

“It’s crucial that ADCS help lead the way in looking at new possibilities for preventing and treating dementia,” Feldman said. “All indicators suggest we can make progress by implementing a wide range of study methods.”

The benfotiamine study continues work funded by the Alzheimer’s Drug Discovery Foundation (ADDF).

“It is gratifying to see research which the ADDF initially identified as promising and supported in a pilot study continue funding from the NIH’s National Institute on Aging,” said Howard Fillit, ADDF co-founder and chief science officer. “With the improved biomarkers that have been developed since the pilot, this next phase will provide a deeper understanding of how benfotiamine works in the brain.”

Joining Feldman and Gibson as a co-principal investigator in the new trial is José Luchsinger, MD, professor of medicine and epidemiology at Columbia University Irving Medical Center.

Additional academic laboratory collaborators include the University of Gothenberg, Sweden; University of Cambridge, UK; and Georgetown University, Washington, D.C. Another study partner is C2N Diagnostics, a St. Louis company focused on advanced brain health diagnostics.

More than 6 million Americans currently live with AD, a figure forecast to rise to nearly 13 million by 2050. Globally, the prevalence of AD is projected to grow from a current 57 million to 153 million in 2050. Currently, there is no cure for AD.

About Alzheimer’s Disease Cooperative Study
The Alzheimer’s Disease Cooperative Study (ADCS) is an academic research organization located at UC San Diego and dedicated to developing treatments for those at risk or affected by Alzheimer’s disease. For upwards of 30 years, with funding including the National Institute on Aging, it has been a field leader in progressing potential new treatments through innovation in clinical trials with design, methods, and analytics. It has a trials coordinating center in San Diego and a network of participating sites across the United States.

About Alzheimer’s Drug Discovery Foundation
Founded in 1998 by Leonard A. and Ronald S. Lauder, the Alzheimer's Drug Discovery Foundation (ADDF) is dedicated to rapidly accelerating the discovery of drugs to prevent, treat and cure Alzheimer's disease. The ADDF is the only public charity solely focused on funding the development of drugs for Alzheimer's, employing a venture philanthropy model to support research in academia and the biotech industry. Through the generosity of its donors, the ADDF has awarded more than $209 million to fund over 690 Alzheimer's drug discovery programs, biomarker programs and clinical trials in 19 countries. To learn more, please visit ADDF’s website.

About Burke Neurological Institute
The Burke Neurological Institute is based in White Plains, NY, and was established in 1978 by Dr. Fletcher McDowell as a research institute dedicated to finding cures for chronic neurological disabilities. The Institute transforms groundbreaking research into clinical treatments so that people can see, talk, and walk again. Their goal is to combine the most rigorous, contemporary brain science with heartfelt compassionate care to innovate and develop novel cures for stable disability in those afflicted with neurological conditions such as stroke, traumatic brain injury or spinal cord injury. Burke Neurological Institute is an academic affiliate of Weill Cornell Medicine.

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I have been taking this supplement for some years now

https://www.lifeextension.com/vitamins- ... -carnosine

is it effective? beats me as I am a crazy as I used to be, my wife could vouch for that but she is too kind. yes she also takes it.
I there is so much worthy news this is just what I find worthy. I am looking to find something special I saw earlier.
Alexia C
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Re: Novel treatment approach to Alzheimer's disease uses vitamin B1 derivative

Post by Alexia C »

Thank you Greyhound! It is always motivating to see more research is being done to understand AD. I am looking forward to see what the results discover as the research moves forward. Best, Alexia C
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floramaria
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Re: Novel treatment approach to Alzheimer's disease uses vitamin B1 derivative

Post by floramaria »

Greyhound wrote: Thu Sep 01, 2022 7:53 pm
I have been taking this supplement for some years now

https://www.lifeextension.com/vitamins- ... -carnosine

is it effective? beats me as I am a crazy as I used to be, my wife could vouch for that but she is too kind. yes she also takes it.
:lol: .."crazy as I used to be". Well, maybe you'd be crazier if you hadn't taken it all these years! :lol:
After reading this article , I did a search online for benfotiamine, and what popped up, top of the page, were two LE benfotiamine supplements. Impossible to keep up with all the supplements!
This is an interesting clinical trial, but it looks like another monotherapy "silver bullet" approach.
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