Anyone have insight on rs2075650?
I’m an E3/4 with A/G alleles which shows increased risk for Alzheimer’s, but have also read that G is linked to E4. Perhaps it’s common to have an E4 and G allele? Maybe 4/4 are commonly G/G and 3/4 AG? Another package deal or is it a separate risk factor?
Thanks for any insight!
rs2075650
Re: rs2075650
Usually a package deal, along with rs4420638.
Re: rs2075650
So no added risk?
https://jamanetwork.com/journals/jamane ... ct/2772020
The article states:
The association between rs2075650 and AD was nominally significant among ε4 homozygotes (model 4) (OR, 1.33; 95% CI, 1.00-1.77; P = .047) but failed to reach significance after APOE adjustment (model 2; OR, 1.09; 95% CI, 0.99-1.19; P = .07) or among ε3 homozygotes (model 3; OR, 1.16; 95% CI, 0.98-1.38; P = .09).
When considering E4 status it seems to add no risk.
Re: rs2075650
So having a G doesn’t increase risk, but an AA might reduce it?
Re: rs2075650
Probably not much, if at all. rs157580 is the TOMM40 SNP that is significantly associated.
Re: rs2075650
Thanks for the feedback. I’m not finding much information with regards to rs157580 and Alzheimer’s risk other than it’s in the large risk pool of genes.
Does the A allele increase risk for E4 carriers or is the risk increase across 3 & 4? I’m a GA so curious as to the amount of increased risk? Thank you again!
Re: rs2075650
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727495/
I’m not sure exactly how the risk is stratified by genotype, but the A is protective.
I’m not sure exactly how the risk is stratified by genotype, but the A is protective.
Re: rs2075650
Thank you for the link and insight. So if I’m deciphering this meta analysis correctly, for caucasians AA very protective, AG somewhat and GG is indifferent so far as it doesn’t magnify risk?Jgreg80 wrote: ↑Mon Sep 26, 2022 10:32 am https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727495/
I’m not sure exactly how the risk is stratified by genotype, but the A is protective.
Re: rs2075650
Depends how you look at it. One could say each G increases risk.
Re: rs2075650
Sorry for all the questions, but what’s the increase in risk with this particular TOMM40 gene? Didn’t see anything in the study. Are the G alleles part of linkage disequilibrium where 4’s typically have a G? Thanks again!