Novel Blood Test Detects Alzheimer's Neurodegeneration

[mike]

Brain-derived tau distinguished Alzheimer's from other dementias

Not sure if this has already been posted... A blood (not CSF) test to determine if you have AD, and how much degeneration exists.

https://www.medpagetoday.com/neurology/ ... definition

[NF52]

Brain-derived tau distinguished Alzheimer's from other dementias

Not sure if this has already been posted... A blood (not CSF) test to determine if you have AD, and how much degeneration exists.

https://www.medpagetoday.com/neurology/ ... definition

This is an exciting development, but will probably be a few years before it's used in clinical trials, and even longer before it's approved by the FDA or European regulators for clinical practice. Currently several large Phase III trials of various drugs (lecanemab, donanemab, ALZ-801) are using blood samples of participants to determine if some other blood tests for different types of tau predict both PET scan results and, more importantly, cognitive changes over time.

. The researchers plan to conduct large-scale clinical validation of blood brain-derived-tau in a wide range of cohorts including ones with diverse racial and ethnic backgrounds. Studies will include older adults with no biological evidence of Alzheimer's disease as well as those at different stages of the disease.