1. This article suggests that rs5882 having at least one G allele can reduce the speed of memory decrease:
2. This article (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015254/) suggests that
3. This article (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530968/) suggests that high HDL might prevent brain from inflammatory and memory deficit.The findings of this study indicated that individuals with the AG+GG genotypes of rs5882 exhibit a significant increment in HDL-C and reduction in BP with lower intakes of total dietary fat, MUFA, and trans-fatty acids compared to individuals with the AA genotype.
Combining these three articles, it seems that rs5882 is protective as it increases HDL while lows bp when you eat healthy.