British Medical Journal - New Study Lifestyle and Memory Decline

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TLS
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British Medical Journal - New Study Lifestyle and Memory Decline

Post by TLS »

An interesting new study was published in the BMJ with results similar to other studies looking at diet and lifestyle. APOE 4 is included.

Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study https://www.bmj.com/content/380/bmj-2022-072691

Objective To identify an optimal lifestyle profile to protect against memory loss in older individuals.

Design Population based, prospective cohort study.

Setting Participants from areas representative of the north, south, and west of China. Participants Individuals aged 60 years or older who had normal cognition and underwent apolipoprotein E (APOE) genotyping at baseline in 2009.

All participants were tested for APOE status.

Conclusions
The results of this study provide strong evidence that adherence to a healthy lifestyle with a combination of positive behaviours, such as never or former smoking, never drinking, a healthy diet, regular physical exercise, and active cognitive activity and social contact, is associated with a slower rate of memory decline. Importantly, our study provides evidence that these effects also include individuals with the APOE ε4 allele. This study might offer important information to protect older adults against memory decline.
apoe 3/4
Jasper
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Re: British Medical Journal - New Study Lifestyle and Memory Decline

Post by Jasper »

It was an interesting article, though given the increased risk in homozygotes versus heterozygotes, it would have been nice if the researchers could tease apart E3/E4 and E4/E4 carriers.
Jay Ess
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Re: British Medical Journal - New Study Lifestyle and Memory Decline

Post by Jay Ess »

One thing I note is that APOE4 carriers with a healthy lifestyle declined more slowly than APOE4 non-carriers with an unhealthy lifestyle. So that's encouraging.
circular
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Re: British Medical Journal - New Study Lifestyle and Memory Decline

Post by circular »

Jasper wrote: Sat Jan 28, 2023 8:32 am It was an interesting article, though given the increased risk in homozygotes versus heterozygotes, it would have been nice if the researchers could tease apart E3/E4 and E4/E4 carriers.
Good point. In large enough studies this should be standard protocol (IMH, non-professional, opinion).
ApoE 3/4 > Thanks in advance for any responses made to my posts.
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