Brian4 wrote: ↑Tue Mar 05, 2024 5:36 pm
Aphorist. Good question. The Alzheon studies didn't look at different time of day dosing. I'm not sure it would make a huge difference, but, like you, I haven't yet fully digested the Nemergut paper.
I'm aiming for the apoE4 structure corrector function, which makes me want to take homotaurine throughout the day.
Thanks Brian. What makes you so sure that taking it throughout the day is ideal? Is it out of precaution to make sure its always available?
I guess I am just naturally skeptical and think there is probably a time of day / circadian effect that is more optimal. We know there is a daily pattern of NAD+ fluctuation. We know there is a circadian build up and clearance of oxidized lipids from neurons to astrocytes. Half-life is ~5-6 hrs of homotaurine?
Maybe mid-day is optimal or the first 6-8 hrs of the day.
It's early days with this research, so I'm not sure of anything. But if homotaurine is a structure corrector, I'd want it to correct my apoE4 all the time. ApoE4 might help with brain development, but after childhood, I think its function is likely purely deleterious -- morning, noon, night. But who knows? Maybe it can have a positive effect in a sort of hormetic way? A couple hours/day?
Thanks for this thread. I started homotaurine 2 days ago, 100mg once daily. The first dose went fine but the second made me vomit. Hoping this gets better with time or maybe with a decrease in dose and/or giving with food?
Thanks for this thread. I started homotaurine 2 days ago, 100mg once daily. The first dose went fine but the second made me vomit. Hoping this gets better with time or maybe with a decrease in dose and/or giving with food?
Big hugs to you. I had the EXACT same experience- bleh. When I vomited, I had taken it with other supps on an empty stomach. When I took it at night without incident (also with other supps) I felt fine. My guess is that I still had food in my stomach which may have helped. Shug, did you also have an empty stomach when you got sick?
FWIW, given the relatively small effects reported from the last ALZ-801 update, I've abandoned this for now but am open to re-trying. It's tricky to take it multiple time per day as an OMAD eater. I'm hopeful that all of the other strategies I'm using are protecting me.
Hi Julie. What were the results from the last ALZ-801 update?
Definitely good, but not earth shattering. I'd be onboard if it didn't make me sick. You can read in this thread.
I also wonder about the integrity of ingredients in the Smart Homataurine. I wish there was some independent validation. A physician friend of mine reached out to the company with this question and she never received an answer.
I take it daily. It took me a couple of weeks of titrating the dose to fully get use to it with zero side effects. I would try a smaller dose and then titrating it up to the suggested amount over 2-4 weeks. Good luck.
Laurence wrote: ↑Tue Nov 14, 2023 6:05 pm
Tinnitus increase is there but reduced from yesterdays peak when it returned to barely noticeable after around 7 hours.
Thank you for reporting your experience! I've got tinnitus from an airbag deployment in a car 15+ years ago. I've not noticed any increase from consuming 150 mg of the SuperSmart brand homotaurine in the morning and 50 mg before bed.
