Homotaurine (tramiprosate) appears to be a structure corrector

[Brian4]

https://molecularneurodegeneration.biom ... 23-00620-9

This is amazing news. It would explain why trials show an allele-dose effect (homozygote > heterozygote > non-carrier).

Although note that an older paper suggests that the molecule being corrected is Aβ42:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488121/

Homotaurine may of course be correcting both.

I'm taking 100 mg t.i.d. Experiencing the unfortunately common nausea side effect, but hoping that will go away soon.

Brian

[Tincup]

I'm taking 100 mg t.i.d. Experiencing the unfortunately common nausea side effect, but hoping that will go away soon.

Curious how long you've been taking at this dose? I've been taking 50 mg q.d. for quite a while, with no side effects. So has my 4/4 wife. Perhaps I should up her dose to 100 t.i.d.

[Brian4]

I just started three days ago. So I'm hoping that the nausea -- experienced by around 20-25% of the people who take homotaurine -- is just me adjusting, or caused by something else.

My still somewhat cursory look at the literature (I'll be diving in more deeply soon) made me conclude that the best dose was at least 300 mg/day -- for heterozygotes or homozygotes. In most of the studies that was typically prescribed as 150 mg b.i.d., but that's a standard bow to compliance worries. A more even dose makes more sense, hence my choice to spread it out more.

Your wife might consider ramping up slowly.

If my nausea doesn't go away I'm going to do a bulk order of valiltramiprosate (valylamide prodrug of homotaurine) from a chemical supply house.

[Tincup]

I just started three days ago. So I'm hoping that the nausea -- experienced by around 20-25% of the people who take homotaurine -- is just me adjusting, or caused by something else.

Don't know if you saw this post from 2020 and its follow up.

Based on these, I used 50 mg/week for quite a while, then upped it to 50/day.

[Brian4]

Thanks Tincup. Yes, I saw the older thread. One of the things I cherish about this group are the detailed reports from people about their self-experimentation. I always take those reports into account when making my own health decisions. But I also look closely at published science. My take-away about dosing from the published studies is: the higher the better (to tolerance), up to 300 mg / day. (And who knows? Even higher might be better.)

Because responses are so individualized, I'm not surprised that some people would experience strong effects (positive or negative) at very low doses.

So far, I've noticed no changes at all, aside from the nausea (which, today, is absent).

Brian

[Brian4]

If my nausea doesn't go away I'm going to do a bulk order of valiltramiprosate (valylamide prodrug of homotaurine) from a chemical supply house.

Actually... no: I can't find a non–prohibitively high price.

Since yesterday the nausea is mostly gone, fortunately (and that, despite having COVID and being on Paxlovid). So I will just keep taking 300 mg homotaurine, in three divided doses.

Brian

[Tincup]

Actually... no: I can't find a non–prohibitively high price.

"prohibitively high price" - from a cursory look a grand understatement!

[KathleenC]

If my nausea doesn't go away I'm going to do a bulk order of valiltramiprosate (valylamide prodrug of homotaurine) from a chemical supply house.

Actually... no: I can't find a non–prohibitively high price.

Since yesterday the nausea is mostly gone, fortunately (and that, despite having COVID and being on Paxlovid). So I will just keep taking 300 mg homotaurine, in three divided doses.

Brian

Hi Brian. Can you share what brand homotaurine you are using? Thanks so much.
Kathleen

[Brian4]

Hi Kathleen. I get it here:

https://www.supersmart.com/en/shop/brai ... ement-0661

I'm currently taking 300 mg/day in divided doses.

Brian

[Julie G]

Thanks for sharing this! I am very excited by tramiprosate for E4 homozygotes especially. This seems to be one of the few pharmaceuticals that is being studied for our population that is showing benefit without risk of severe side effects. The fact that it's currently available OTC is a bonus. FWIW, the dosage that Brian is using (300 mg) is the one that has been shown to have benefit. I'm following closely.