Homotaurine (tramiprosate) appears to be a structure corrector

[Fiver]

I'll experiment with the timing and see if that helps. So glad you mentioned your experience. I was expecting nausea, not those other symptoms. I'll just try to get through it - maybe they'll go away.

[Veero]

Funny enough a homotaurine derivative used in alcohol dependence therapy
https://en.wikipedia.org/wiki/Acamprosate
has insomnia listed as a side effect.

[Tabby]

I took my first 50 mg cap yesterday with food and felt terrible. I get nauseous easily and have to take vitamins with a large amount of food, so I am not surprised. I would love to find a form that I can handle working up to the higher dose. I did not notice the other side effects, but I was pretty focused on how nauseated I was.

[Veero]

I have considered ordering empty capsules and dividing up the 50 into 25 mg ones to use for a while to adapt to the dose.

[Fiver]

Quick update. Taking it at night seems to work great for me. No nausea. Sleep great. And wake up feeling good. I think maybe the effect builds overnight kicks in when it's time to wake up anyway.

[Veero]

Wow I think someone else mentioned that at night things went well. You take at bedtime presumably?

[Downtown]

I have been taking it for a month 150mg bid. I titrated the amounts for two weeks until I got to the recommended dose. I had some nausea for about 3 weeks about 2.5-3 hrs after taking a dose with a meal. Now I have no nausea at all.

[LisaJS]

I’ve started with 50mg bid and have not experienced any side effects at all. I’m thinking I might stay at this dose for the foreseeable future since I’m in my 40s and it’s expensive to take the full experimental dose. Hoping it will still offer some benefit.

[Tincup]

I’ve started with 50mg bid and have not experienced any side effects at all. I’m thinking I might stay at this dose for the foreseeable future since I’m in my 40s and it’s expensive to take the full experimental dose. Hoping it will still offer some benefit.

You might be interested in this guy's posts on lower doses:

viewtopic.php?p=77568#p77568
viewtopic.php?p=79618#p79618

[JennyR]

I have been taking it for a month 150mg bid. I titrated the amounts for two weeks until I got to the recommended dose. I had some nausea for about 3 weeks about 2.5-3 hrs after taking a dose with a meal. Now I have no nausea at all.

Hi Downtown and welcome to the Forum! It looks like you're new here and I love that you jumped right in. Thank you for sharing your experience with homotaurine--glad you've been able to keep the nausea at bay.

As a Support Team Intern, I wanted to share a few additional tools & resources to help you get the most out of your experience here if you would like to explore the site in more detail. Ignore if you've already found your way!

The Primer is a detailed and informative resource written by a practicing M.D. with ApoE4/4. It includes information about the biochemistry of the ApoE4 gene and offers a variety of research-based prevention strategies.

Some helpful tips to navigate the site include the How-to-Guide. It includes topics such as navigating the forum, private messaging, and searching.

If you are interested in learning more about other members, check out Our Stories. If and when you're comfortable, we'd love to hear your story! Although everyone here has a unique and bio-individual journey, there's a lot to be gleaned from the experiences of others going through similar situations. At the least, you'll remember that you're not alone!

Again, welcome to the Forum. Please feel free to reach out anytime with additional questions and keep us posted on your journey.

With love, in health,
Jenny