Question about new research on lysosomal autophagy

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cdaniel
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Question about new research on lysosomal autophagy

Post by cdaniel »

I read a story today about a study that came out in January about druggable sites in ApoE4 and it found something they referred to as CBA2 as a candidate for a drug to improve lysosomal autophagy.

Story: https://medicalxpress.com/news/2024-02- ... -drug.html
Research: https://www.nature.com/articles/s42003-024-05767-9

It's way over my head and I'd like to understand it a little bit more. Is there anyone who understands this research approach that can translate it into layman's terms, and can you decipher what CBA2 is exactly?

Thanks!
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TheresaB
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Re: Question about new research on lysosomal autophagy

Post by TheresaB »

cdaniel wrote: Wed Feb 07, 2024 11:22 am I read a story today about a study that came out in January about druggable sites in ApoE4 and it found something they referred to as CBA2 as a candidate for a drug to improve lysosomal autophagy.

Story: https://medicalxpress.com/news/2024-02- ... -drug.html
Research: https://www.nature.com/articles/s42003-024-05767-9

It's way over my head and I'd like to understand it a little bit more. Is there anyone who understands this research approach that can translate it into layman's terms, and can you decipher what CBA2 is exactly?

Thanks!
Given that a potential drug, if found promising, can be patented and sold by a pharmaceutical company, deciphering CBA2 exactly would likely mean violating non-disclosure agreements.

Referencing the quote
"Our hope is that people who have one or two copies of APOEε4 will one day take the drug regularly throughout their life and significantly reduce their risk of developing Alzheimer's disease," Griffin said.
My guess it is a corrector on the ApoE4 protein to facilitate brain cells disposing of their waste products (lysosomal autophagy) an impaired process in ε4s.
-Theresa
ApoE 4/4
Fiver
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Re: Question about new research on lysosomal autophagy

Post by Fiver »

Thanks for sharing this article. The endosomal/lysosomal system for taking molecules into the cell, releasing the useful ones, and digesting the rest is disrupted by apoe4. It creates a bit of a traffic jam there.

If these hypothetical drugs fix the structure of apoe4 and gets this system flowing again that would be really exciting!
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